An Integrated Thermal Actuation/Sensing Array with Stacked Oscillators for Efficient and Localized Heating of Magnetic Nanoparticles with Sub-Millimeter Spatial Resolution

Yingying Fan; Linlin Zhang; Qingbo Zhang; Gang Bao; Taiyun Chi

doi:10.1109/ISSCC42613.2021.9365940

An Integrated Thermal Actuation/Sensing Array with Stacked Oscillators for Efficient and Localized Heating of Magnetic Nanoparticles with Sub-Millimeter Spatial Resolution

Yingying Fan, Linlin Zhang, Qingbo Zhang, Gang Bao, Taiyun Chi

Department of Electrical & Systems Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Scopus citations

Abstract

Magnetic nanoparticles (MNP) can generate localized thermal stress in response to an external ac magnetic field, offering unique opportunities for a wide range of biomedical applications. For example, hyperthermia cancer therapy, which raises the local temperature of tumors up to 43-45°C, can trigger apoptosis and disrupt cancer cells' ability to repair DNA damage [1]. In neuroscience, temperature-sensitive ion channels can be thermally activated using MNP-induced heating, which allows for minimally invasive brain stimulation [2,3]. Compared to dielectric heating and ohmic heating, MNP-based magnetic heating offers superior specificity and minimal damage to the surrounding tissues since most biological systems are non-magnetic.

Original language	English
Title of host publication	2021 IEEE International Solid-State Circuits Conference, ISSCC 2021 - Digest of Technical Papers
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	280-282
Number of pages	3
ISBN (Electronic)	9781728195490
DOIs	https://doi.org/10.1109/ISSCC42613.2021.9365940
State	Published - Feb 13 2021
Event	2021 IEEE International Solid-State Circuits Conference, ISSCC 2021 - San Francisco, United States Duration: Feb 13 2021 → Feb 22 2021

Publication series

Name	Digest of Technical Papers - IEEE International Solid-State Circuits Conference
Volume	64
ISSN (Print)	0193-6530

Conference

Conference	2021 IEEE International Solid-State Circuits Conference, ISSCC 2021
Country/Territory	United States
City	San Francisco
Period	02/13/21 → 02/22/21

Access to Document

10.1109/ISSCC42613.2021.9365940

Cite this

Fan, Y., Zhang, L., Zhang, Q., Bao, G., & Chi, T. (2021). An Integrated Thermal Actuation/Sensing Array with Stacked Oscillators for Efficient and Localized Heating of Magnetic Nanoparticles with Sub-Millimeter Spatial Resolution. In 2021 IEEE International Solid-State Circuits Conference, ISSCC 2021 - Digest of Technical Papers (pp. 280-282). Article 9365940 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 64). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ISSCC42613.2021.9365940

Fan, Yingying ; Zhang, Linlin ; Zhang, Qingbo et al. / An Integrated Thermal Actuation/Sensing Array with Stacked Oscillators for Efficient and Localized Heating of Magnetic Nanoparticles with Sub-Millimeter Spatial Resolution. 2021 IEEE International Solid-State Circuits Conference, ISSCC 2021 - Digest of Technical Papers. Institute of Electrical and Electronics Engineers Inc., 2021. pp. 280-282 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference).

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title = "An Integrated Thermal Actuation/Sensing Array with Stacked Oscillators for Efficient and Localized Heating of Magnetic Nanoparticles with Sub-Millimeter Spatial Resolution",

abstract = "Magnetic nanoparticles (MNP) can generate localized thermal stress in response to an external ac magnetic field, offering unique opportunities for a wide range of biomedical applications. For example, hyperthermia cancer therapy, which raises the local temperature of tumors up to 43-45°C, can trigger apoptosis and disrupt cancer cells' ability to repair DNA damage [1]. In neuroscience, temperature-sensitive ion channels can be thermally activated using MNP-induced heating, which allows for minimally invasive brain stimulation [2,3]. Compared to dielectric heating and ohmic heating, MNP-based magnetic heating offers superior specificity and minimal damage to the surrounding tissues since most biological systems are non-magnetic.",

author = "Yingying Fan and Linlin Zhang and Qingbo Zhang and Gang Bao and Taiyun Chi",

note = "Publisher Copyright: {\textcopyright} 2021 IEEE.; 2021 IEEE International Solid-State Circuits Conference, ISSCC 2021 ; Conference date: 13-02-2021 Through 22-02-2021",

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doi = "10.1109/ISSCC42613.2021.9365940",

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Fan, Y, Zhang, L, Zhang, Q, Bao, G & Chi, T 2021, An Integrated Thermal Actuation/Sensing Array with Stacked Oscillators for Efficient and Localized Heating of Magnetic Nanoparticles with Sub-Millimeter Spatial Resolution. in 2021 IEEE International Solid-State Circuits Conference, ISSCC 2021 - Digest of Technical Papers., 9365940, Digest of Technical Papers - IEEE International Solid-State Circuits Conference, vol. 64, Institute of Electrical and Electronics Engineers Inc., pp. 280-282, 2021 IEEE International Solid-State Circuits Conference, ISSCC 2021, San Francisco, United States, 02/13/21. https://doi.org/10.1109/ISSCC42613.2021.9365940

An Integrated Thermal Actuation/Sensing Array with Stacked Oscillators for Efficient and Localized Heating of Magnetic Nanoparticles with Sub-Millimeter Spatial Resolution. / Fan, Yingying; Zhang, Linlin; Zhang, Qingbo et al.
2021 IEEE International Solid-State Circuits Conference, ISSCC 2021 - Digest of Technical Papers. Institute of Electrical and Electronics Engineers Inc., 2021. p. 280-282 9365940 (Digest of Technical Papers - IEEE International Solid-State Circuits Conference; Vol. 64).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Bao, Gang

AU - Chi, Taiyun

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N2 - Magnetic nanoparticles (MNP) can generate localized thermal stress in response to an external ac magnetic field, offering unique opportunities for a wide range of biomedical applications. For example, hyperthermia cancer therapy, which raises the local temperature of tumors up to 43-45°C, can trigger apoptosis and disrupt cancer cells' ability to repair DNA damage [1]. In neuroscience, temperature-sensitive ion channels can be thermally activated using MNP-induced heating, which allows for minimally invasive brain stimulation [2,3]. Compared to dielectric heating and ohmic heating, MNP-based magnetic heating offers superior specificity and minimal damage to the surrounding tissues since most biological systems are non-magnetic.

AB - Magnetic nanoparticles (MNP) can generate localized thermal stress in response to an external ac magnetic field, offering unique opportunities for a wide range of biomedical applications. For example, hyperthermia cancer therapy, which raises the local temperature of tumors up to 43-45°C, can trigger apoptosis and disrupt cancer cells' ability to repair DNA damage [1]. In neuroscience, temperature-sensitive ion channels can be thermally activated using MNP-induced heating, which allows for minimally invasive brain stimulation [2,3]. Compared to dielectric heating and ohmic heating, MNP-based magnetic heating offers superior specificity and minimal damage to the surrounding tissues since most biological systems are non-magnetic.

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M3 - Conference contribution

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Fan Y, Zhang L, Zhang Q, Bao G, Chi T. An Integrated Thermal Actuation/Sensing Array with Stacked Oscillators for Efficient and Localized Heating of Magnetic Nanoparticles with Sub-Millimeter Spatial Resolution. In 2021 IEEE International Solid-State Circuits Conference, ISSCC 2021 - Digest of Technical Papers. Institute of Electrical and Electronics Engineers Inc. 2021. p. 280-282. 9365940. (Digest of Technical Papers - IEEE International Solid-State Circuits Conference). doi: 10.1109/ISSCC42613.2021.9365940

An Integrated Thermal Actuation/Sensing Array with Stacked Oscillators for Efficient and Localized Heating of Magnetic Nanoparticles with Sub-Millimeter Spatial Resolution

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