TY - JOUR
T1 - An institutional strategy to increase minority recruitment to therapeutic trials
AU - Anwuri, Victoria V.
AU - Hall, Lannis E.
AU - Mathews, Katherine
AU - Springer, Brian C.
AU - Tappenden, Jennifer R.
AU - Farria, Dione M.
AU - Jackson, Sherrill
AU - Goodman, Melody S.
AU - Eberlein, Timothy J.
AU - Colditz, Graham A.
N1 - Funding Information:
Acknowledgments This work was supported by the National Cancer Institute at the National Institutes of Health (U01CA114594, U54CA153460, and P30CA91842).
PY - 2013/10
Y1 - 2013/10
N2 - Purpose: Participation in therapeutic clinical trials rarely reflects the race and ethnic composition of the patient population. To meet National Institutes of Health-mandated goals, strategies to increase participation are required. We present a framework for institutional enhancement of minority clinical trial accrual. Methods: We implemented structural changes on four levels to induce and sustain minority accrual to clinical trials: (1) leadership support; (2) center-wide policy change; (3) infrastructural process control, data analysis, and reporting; and (4) follow-up with clinical investigators. A Protocol Review and Monitoring Committee reviews studies and monitors accrual, and the Program for the Elimination Cancer Disparities leads efforts for proportional accrual, supporting the system through data tracking, Web tools, and feedback to investigators. Results: Following implementation in 2005, minority accrual to therapeutic trials increased from 12.0 % in 2005 to 14.0 % in 2010. The "rolling average" minority cancer incidence at the institution during this timeframe was 17.5 %. In addition to therapeutic trial accrual rates, we note significant increase in the number of minorities participating in all trials (therapeutic and nontherapeutic) from 2005 to 2010 (346-552, 60 % increase, p < 0.05) compared to a 52 % increase for Caucasians. Conclusions: Implementing a system to aid investigators in planning and establishing targets for accrual, while requiring this component as a part of annual protocol review and monitoring of accrual, offers a successful strategy that can be replicated in other cancer centers, an approach that may extend to other clinical and translational research centers.
AB - Purpose: Participation in therapeutic clinical trials rarely reflects the race and ethnic composition of the patient population. To meet National Institutes of Health-mandated goals, strategies to increase participation are required. We present a framework for institutional enhancement of minority clinical trial accrual. Methods: We implemented structural changes on four levels to induce and sustain minority accrual to clinical trials: (1) leadership support; (2) center-wide policy change; (3) infrastructural process control, data analysis, and reporting; and (4) follow-up with clinical investigators. A Protocol Review and Monitoring Committee reviews studies and monitors accrual, and the Program for the Elimination Cancer Disparities leads efforts for proportional accrual, supporting the system through data tracking, Web tools, and feedback to investigators. Results: Following implementation in 2005, minority accrual to therapeutic trials increased from 12.0 % in 2005 to 14.0 % in 2010. The "rolling average" minority cancer incidence at the institution during this timeframe was 17.5 %. In addition to therapeutic trial accrual rates, we note significant increase in the number of minorities participating in all trials (therapeutic and nontherapeutic) from 2005 to 2010 (346-552, 60 % increase, p < 0.05) compared to a 52 % increase for Caucasians. Conclusions: Implementing a system to aid investigators in planning and establishing targets for accrual, while requiring this component as a part of annual protocol review and monitoring of accrual, offers a successful strategy that can be replicated in other cancer centers, an approach that may extend to other clinical and translational research centers.
KW - Clinical trial
KW - Disparities
KW - Enrollment
KW - Minority
KW - Participation
KW - Therapeutic trial
UR - http://www.scopus.com/inward/record.url?scp=84884595526&partnerID=8YFLogxK
U2 - 10.1007/s10552-013-0258-1
DO - 10.1007/s10552-013-0258-1
M3 - Article
C2 - 23846282
AN - SCOPUS:84884595526
SN - 0957-5243
VL - 24
SP - 1797
EP - 1809
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 10
ER -