An in vivo evaluation of *I-fibrinogen labeled by four different methods

R. Edward Coleman, Kenneth R. Krohn, Judith M. Metzger, Michael J. Welch, Roger H. Secker-Walker, Barry A. Siegel

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20 Scopus citations


The thrombus uptake of radioiodinated fibrinogen prepared by either the iodine monochloride, chloramine-T, electrolytic, or enzymatic method was compared in dogs using a surgical model of venous thrombosis. The labeled fibrinogen uptake into thrombi was measured by external scintillation counting in vivo and in vitro determination of thrombus-to-blood ratios. The iodine monochloride preparations resulted in the greatest fibrinogen uptake and the highest thrombus-to-blood ratios. The uptake of enzymatically labeled fibrinogen most closely approached that of the iodine monochloride preparations. The chloramine-T and electrolytic preparations of fibrinogen were less satisfactory since these methods either alter the fibrinogen or produce unstable labeling of the fibrinogen.

Original languageEnglish
Pages (from-to)977-982
Number of pages6
JournalThe Journal of Laboratory and Clinical Medicine
Issue number6
StatePublished - Jun 1974


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