TY - JOUR
T1 - An improved synthesis of the dopamine autoreceptor antagonist (+)-cis-8-methoxy-1-methyl-2-(dipropylamino)tetralin (AJ-76)
AU - Romero, Arthur G.
AU - Leiby, Jeffrey A.
PY - 1992/12
Y1 - 1992/12
N2 - A new and efficient synthesis of (+)-cis-8-methoxy-1-methyl-2-(dipropylamino)tetralin, AJ-76, and its monopropyl analog, UH-232, was achieved. Relative stereochemistry was controlled by doubled bond hydrogenation, followed by enantiomeric resolution with quinine to obtain optically pure material. Overall, AJ-76 is synthesized in 9 percent overall yield, including the optical resolution.
AB - A new and efficient synthesis of (+)-cis-8-methoxy-1-methyl-2-(dipropylamino)tetralin, AJ-76, and its monopropyl analog, UH-232, was achieved. Relative stereochemistry was controlled by doubled bond hydrogenation, followed by enantiomeric resolution with quinine to obtain optically pure material. Overall, AJ-76 is synthesized in 9 percent overall yield, including the optical resolution.
UR - http://www.scopus.com/inward/record.url?scp=0026729839&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(00)80457-6
DO - 10.1016/S0960-894X(00)80457-6
M3 - Article
AN - SCOPUS:0026729839
SN - 0960-894X
VL - 2
SP - 1691
EP - 1692
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 12
ER -