An improved synthesis of the dopamine autoreceptor antagonist (+)-cis-8-methoxy-1-methyl-2-(dipropylamino)tetralin (AJ-76)

Arthur G. Romero, Jeffrey A. Leiby

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A new and efficient synthesis of (+)-cis-8-methoxy-1-methyl-2-(dipropylamino)tetralin, AJ-76, and its monopropyl analog, UH-232, was achieved. Relative stereochemistry was controlled by doubled bond hydrogenation, followed by enantiomeric resolution with quinine to obtain optically pure material. Overall, AJ-76 is synthesized in 9 percent overall yield, including the optical resolution.

Original languageEnglish
Pages (from-to)1691-1692
Number of pages2
JournalBioorganic and Medicinal Chemistry Letters
Volume2
Issue number12
DOIs
StatePublished - Dec 1992

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