TY - JOUR
T1 - An experimental model for the study of canine flexor tendon adhesions
AU - Rothkopf, Douglas M.
AU - Webb, Sharon
AU - Szabo, Robert M.
AU - Gelberman, Richard H.
AU - May, James W.
N1 - Funding Information:
From the Division of Plastic and Reconstructive Surgery, Department of General Surgery, and the Department of Orthopaedic Surgery, Massachusetts General Hospital. Harvard Medical School, Boston, Mass.; and the Hand and Upper Extremity Service, Department of Orthopaedic Surgery, University of California, Davis, Sacra-mento, Calif. Funded by the Genentech Corporation project. Additional support provided by NIH Grant No. 2ROl-AR33-97-11. Received for publication Sept. 8, 1989; accepted in revised form April 13, 1990. No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article. Reprint requests: James W. May, Jr., MD, Massachusetts General Hospital, ACC 3A, Suite 353, Boston, MA 02114. 3/I/22360
PY - 1991/7
Y1 - 1991/7
N2 - An experimental model for the study of canine flexor tendon adhesions was designed using a standardized crush-abrasion injury, meticulous sheath closure, and three-week limb immobilization. Ten animals in the experimental protocol were evaluated for visible adhesion formation. With use of a flexor tendon adhesion rating scale, consistent adhesion formation was documented with an average score of 10.4 ± 2.1 (range, 0 to 12). Five additional animals had biomechanical testing. Applying an increasing load to the proximally divided profundus tendon (0 to 10 Newtons), it was found that the angle of distal interphalangeal joint motion and the displacement of the toe were significantly decreased, and the work generated significantly increased in the experimental versus control digits (p < 0.05). The consistent production of visible adhesions thus correlates with biomechanical impairments in toe motion and work. The study of agents aimed at diminishing flexor tendon adhesions will thus be facilitated by this reliable model. Systemic or intrasheath administration of agents will be possible.
AB - An experimental model for the study of canine flexor tendon adhesions was designed using a standardized crush-abrasion injury, meticulous sheath closure, and three-week limb immobilization. Ten animals in the experimental protocol were evaluated for visible adhesion formation. With use of a flexor tendon adhesion rating scale, consistent adhesion formation was documented with an average score of 10.4 ± 2.1 (range, 0 to 12). Five additional animals had biomechanical testing. Applying an increasing load to the proximally divided profundus tendon (0 to 10 Newtons), it was found that the angle of distal interphalangeal joint motion and the displacement of the toe were significantly decreased, and the work generated significantly increased in the experimental versus control digits (p < 0.05). The consistent production of visible adhesions thus correlates with biomechanical impairments in toe motion and work. The study of agents aimed at diminishing flexor tendon adhesions will thus be facilitated by this reliable model. Systemic or intrasheath administration of agents will be possible.
UR - http://www.scopus.com/inward/record.url?scp=0025787528&partnerID=8YFLogxK
U2 - 10.1016/0363-5023(91)90196-I
DO - 10.1016/0363-5023(91)90196-I
M3 - Article
C2 - 1880368
AN - SCOPUS:0025787528
SN - 0363-5023
VL - 16
SP - 694
EP - 700
JO - Journal of Hand Surgery
JF - Journal of Hand Surgery
IS - 4
ER -