TY - JOUR
T1 - An ex vivo comparison of vascular access devices used in extracorporeal photopheresis
AU - Szymanski, Jeffrey
AU - Shah, Priyank
AU - Dynis, Marian
AU - Mansfield, Donna
AU - Hamilton, Connie
AU - Despotis, George
N1 - Funding Information:
George Despotis discloses the following relevant financial relationship: an unrestricted research grant from Therakos, Inc., a Mallinckrodt Pharmaceuticals company, for his role as PI of a multicenter project co-sponsored by Medicare through the CED path (CAG-00324R2 Version 7 NCT02181257) investigating the efficacy of ECP to arrest BOS in lung transplant recipients.
Publisher Copyright:
© 2018 AABB
PY - 2018/2
Y1 - 2018/2
N2 - BACKGROUND: Central venous access devices are commonly used in extracorporeal photopheresis, but their performance has not been systematically evaluated. The primary objective of this study was to compare pressures at various flow rates for central venous access devices in an ex vivo simulation of photopheresis. STUDY DESIGN AND METHODS: Diluted, heparinized red blood cells were circulated through central access devices in series with a photopheresis system, and pressures at several flow rates were recorded. The devices tested were the Trifusion catheter (Hickman), the Vortex single-lumen and dual-lumen ports (Angiodynamics), and the TidalPort device (Norfolk). Flow rates were also compared for silicone and polyurethane catheters and for different catheter internal diameters. RESULTS: The Vortex dual-lumen port generated pressure alarms above flow rates of 60 mL/minute. Throughout flow rates from 5 to 100 mL/minute, the Trifusion catheter and the TidalPort device operated at lower pressures than the Vortex ports. Within typical clinical flow rates, neither catheter material nor internal diameter substantially affected pressure. CONCLUSION: Central venous access devices show large differences in pressure within flow rates used routinely in clinical settings. These differences cannot be fully attributed to catheter material composition or catheter internal diameter.
AB - BACKGROUND: Central venous access devices are commonly used in extracorporeal photopheresis, but their performance has not been systematically evaluated. The primary objective of this study was to compare pressures at various flow rates for central venous access devices in an ex vivo simulation of photopheresis. STUDY DESIGN AND METHODS: Diluted, heparinized red blood cells were circulated through central access devices in series with a photopheresis system, and pressures at several flow rates were recorded. The devices tested were the Trifusion catheter (Hickman), the Vortex single-lumen and dual-lumen ports (Angiodynamics), and the TidalPort device (Norfolk). Flow rates were also compared for silicone and polyurethane catheters and for different catheter internal diameters. RESULTS: The Vortex dual-lumen port generated pressure alarms above flow rates of 60 mL/minute. Throughout flow rates from 5 to 100 mL/minute, the Trifusion catheter and the TidalPort device operated at lower pressures than the Vortex ports. Within typical clinical flow rates, neither catheter material nor internal diameter substantially affected pressure. CONCLUSION: Central venous access devices show large differences in pressure within flow rates used routinely in clinical settings. These differences cannot be fully attributed to catheter material composition or catheter internal diameter.
UR - http://www.scopus.com/inward/record.url?scp=85042138160&partnerID=8YFLogxK
U2 - 10.1111/trf.14482
DO - 10.1111/trf.14482
M3 - Article
C2 - 29443412
AN - SCOPUS:85042138160
SN - 0041-1132
VL - 58
SP - 609
EP - 613
JO - Transfusion
JF - Transfusion
ER -