19 Scopus citations


Kim et al. identify a sequence insertion in the Mxra8 receptor of Bovinae species that prevents alphavirus binding. Deletion of the Bovinae Mxra8 insertion restores alphavirus infection, while mice engineered with the Mxra8 insertion exhibit reduced CHIKV infection. Identification of this insertion could facilitate countermeasures preventing Mxra8 engagement of alphaviruses.

Original languageEnglish
Pages (from-to)428-440.e9
JournalCell Host and Microbe
Issue number3
StatePublished - Mar 11 2020


  • Bovinae
  • X-ray crystallography
  • alphavirus
  • evolution
  • infection
  • pathogenesis
  • receptor


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