Kim et al. identify a sequence insertion in the Mxra8 receptor of Bovinae species that prevents alphavirus binding. Deletion of the Bovinae Mxra8 insertion restores alphavirus infection, while mice engineered with the Mxra8 insertion exhibit reduced CHIKV infection. Identification of this insertion could facilitate countermeasures preventing Mxra8 engagement of alphaviruses.
- X-ray crystallography