An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis

Arthur S. Kim, Ofer Zimmerman, Julie M. Fox, Christopher A. Nelson, Katherine Basore, Rong Zhang, Lorellin Durnell, Chandni Desai, Christopher Bullock, Sharon L. Deem, Jonas Oppenheimer, Beth Shapiro, Ting Wang, Sara Cherry, Carolyn B. Coyne, Scott A. Handley, Michael J. Landis, Daved H. Fremont, Michael S. Diamond

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Kim et al. identify a sequence insertion in the Mxra8 receptor of Bovinae species that prevents alphavirus binding. Deletion of the Bovinae Mxra8 insertion restores alphavirus infection, while mice engineered with the Mxra8 insertion exhibit reduced CHIKV infection. Identification of this insertion could facilitate countermeasures preventing Mxra8 engagement of alphaviruses.

Original languageEnglish
Pages (from-to)428-440.e9
JournalCell Host and Microbe
Volume27
Issue number3
DOIs
StatePublished - Mar 11 2020

Keywords

  • Bovinae
  • X-ray crystallography
  • alphavirus
  • evolution
  • infection
  • pathogenesis
  • receptor

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    Kim, A. S., Zimmerman, O., Fox, J. M., Nelson, C. A., Basore, K., Zhang, R., Durnell, L., Desai, C., Bullock, C., Deem, S. L., Oppenheimer, J., Shapiro, B., Wang, T., Cherry, S., Coyne, C. B., Handley, S. A., Landis, M. J., Fremont, D. H., & Diamond, M. S. (2020). An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis. Cell Host and Microbe, 27(3), 428-440.e9. https://doi.org/10.1016/j.chom.2020.01.008