@article{12b1d46aca5e4ba1bf101f9071436c65,
title = "An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis",
abstract = "Kim et al. identify a sequence insertion in the Mxra8 receptor of Bovinae species that prevents alphavirus binding. Deletion of the Bovinae Mxra8 insertion restores alphavirus infection, while mice engineered with the Mxra8 insertion exhibit reduced CHIKV infection. Identification of this insertion could facilitate countermeasures preventing Mxra8 engagement of alphaviruses.",
keywords = "Bovinae, X-ray crystallography, alphavirus, evolution, infection, pathogenesis, receptor",
author = "Kim, {Arthur S.} and Ofer Zimmerman and Fox, {Julie M.} and Nelson, {Christopher A.} and Katherine Basore and Rong Zhang and Lorellin Durnell and Chandni Desai and Christopher Bullock and Deem, {Sharon L.} and Jonas Oppenheimer and Beth Shapiro and Ting Wang and Sara Cherry and Coyne, {Carolyn B.} and Handley, {Scott A.} and Landis, {Michael J.} and Fremont, {Daved H.} and Diamond, {Michael S.}",
note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = mar,
day = "11",
doi = "10.1016/j.chom.2020.01.008",
language = "English",
volume = "27",
pages = "428--440.e9",
journal = "Cell Host and Microbe",
issn = "1931-3128",
number = "3",
}