An encyclopedia of mouse genes

Marco Marra; La Deana Hillier; Tamara Kucaba; Melissa Allen; Robert Barstead; Catherine Beck; Angela Blistain; Maria Bonaldo; Yvette Bowers; Louise Bowles; Marco Cardenas; Ann Chamberlain; Julie Chappell; Sandra Clifton; Anthony Favello; Steve Geisel; Marilyn Gibbons; Njata Harvey; Francesca Hill; Yolanda Jackson; Sophie Kohn; Greg Lennon; Elaine Mardis; John Martin; Lee Anne Mila; Rhonda McCann; Richard Morales; Deana Pape; Barry Person; Christa Prange; Erika Ritter; Marcelo Soares; Rebecca Schurk; Tanya Shin; Michele Steptoe; Timothy Swaller; Brenda Theising; Karen Underwood; Todd Wylie; Tamara Yount; Richard Wilson; Robert Waterston

doi:10.1038/5976

An encyclopedia of mouse genes

Marco Marra, La Deana Hillier, Tamara Kucaba, Melissa Allen, Robert Barstead, Catherine Beck, Angela Blistain, Maria Bonaldo, Yvette Bowers, Louise Bowles, Marco Cardenas, Ann Chamberlain, Julie Chappell, Sandra Clifton, Anthony Favello, Steve Geisel, Marilyn Gibbons, Njata Harvey, Francesca Hill, Yolanda JacksonSophie Kohn, Greg Lennon, Elaine Mardis, John Martin, Lee Anne Mila, Rhonda McCann, Richard Morales, Deana Pape, Barry Person, Christa Prange, Erika Ritter, Marcelo Soares, Rebecca Schurk, Tanya Shin, Michele Steptoe, Timothy Swaller, Brenda Theising, Karen Underwood, Todd Wylie, Tamara Yount, Richard Wilson, Robert Waterston

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104 Scopus citations

Abstract

The laboratory mouse is the premier model system for studies of mammalian development due to the powerful classical genetic analysis possible (see also the Jackson Laboratory web site, http://www.jax.org/) and the ever- expanding collection of molecular tools. To enhance the utility of the mouse system, we initiated a program to generate a large database of expressed sequence tags (ESTs) that can provide rapid access to genes. Of particular significance was the possibility that cDNA libraries could be prepared from very early stages of development, a situation unrealized in human EST projects. We report here the development of a comprehensive database of ESTs for the mouse. The project, initiated in March 1996, has focused on 5' end sequences from directionally cloned, oligo-dT primed cDNA libraries. As of 23 October 1998, 352,040 sequences had been generated, annotated and deposited in dbEST, where they comprised 93% of the total ESTs available for mouse. EST data are versatile and have been applied to gene identification, comparative sequence analysis, comparative gene mapping and candidate disease gene identification, genome sequence annotation, microarray development and the development of gene-based map resources.

Original language	English
Pages (from-to)	191-194
Number of pages	4
Journal	Nature Genetics
Volume	21
Issue number	2
DOIs	https://doi.org/10.1038/5976
State	Published - Feb 1999

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@article{67f93da462f840cf94a50edc1f8d6272,

title = "An encyclopedia of mouse genes",

abstract = "The laboratory mouse is the premier model system for studies of mammalian development due to the powerful classical genetic analysis possible (see also the Jackson Laboratory web site, http://www.jax.org/) and the ever- expanding collection of molecular tools. To enhance the utility of the mouse system, we initiated a program to generate a large database of expressed sequence tags (ESTs) that can provide rapid access to genes. Of particular significance was the possibility that cDNA libraries could be prepared from very early stages of development, a situation unrealized in human EST projects. We report here the development of a comprehensive database of ESTs for the mouse. The project, initiated in March 1996, has focused on 5' end sequences from directionally cloned, oligo-dT primed cDNA libraries. As of 23 October 1998, 352,040 sequences had been generated, annotated and deposited in dbEST, where they comprised 93% of the total ESTs available for mouse. EST data are versatile and have been applied to gene identification, comparative sequence analysis, comparative gene mapping and candidate disease gene identification, genome sequence annotation, microarray development and the development of gene-based map resources.",

author = "Marco Marra and Hillier, {La Deana} and Tamara Kucaba and Melissa Allen and Robert Barstead and Catherine Beck and Angela Blistain and Maria Bonaldo and Yvette Bowers and Louise Bowles and Marco Cardenas and Ann Chamberlain and Julie Chappell and Sandra Clifton and Anthony Favello and Steve Geisel and Marilyn Gibbons and Njata Harvey and Francesca Hill and Yolanda Jackson and Sophie Kohn and Greg Lennon and Elaine Mardis and John Martin and Mila, {Lee Anne} and Rhonda McCann and Richard Morales and Deana Pape and Barry Person and Christa Prange and Erika Ritter and Marcelo Soares and Rebecca Schurk and Tanya Shin and Michele Steptoe and Timothy Swaller and Brenda Theising and Karen Underwood and Todd Wylie and Tamara Yount and Richard Wilson and Robert Waterston",

note = "Funding Information: We thank all investigators who have donated libraries for sequencing; S. Tilghman for scientific guidance; S. Chissoe and S. Gorski for comments on the manuscript and useful discussion; G. Schuler, C. Tolstoshev and others at NCBI for assistance with databases; and the staff at Washington University Genome Center for technical support. Work by C.P. and G.L. was supported by the U.S. DOE under contract W-7405-Eng-48 to LLNL. Work at Washington University was funded by a grant from Howard Hughes Medical Institute.",

year = "1999",

month = feb,

doi = "10.1038/5976",

language = "English",

volume = "21",

pages = "191--194",

journal = "Nature Genetics",

issn = "1061-4036",

number = "2",

}

Marra, M, Hillier, LD, Kucaba, T, Allen, M, Barstead, R, Beck, C, Blistain, A, Bonaldo, M, Bowers, Y, Bowles, L, Cardenas, M, Chamberlain, A, Chappell, J, Clifton, S, Favello, A, Geisel, S, Gibbons, M, Harvey, N, Hill, F, Jackson, Y, Kohn, S, Lennon, G, Mardis, E, Martin, J, Mila, LA, McCann, R, Morales, R, Pape, D, Person, B, Prange, C, Ritter, E, Soares, M, Schurk, R, Shin, T, Steptoe, M, Swaller, T, Theising, B, Underwood, K, Wylie, T, Yount, T, Wilson, R & Waterston, R 1999, 'An encyclopedia of mouse genes', Nature Genetics, vol. 21, no. 2, pp. 191-194. https://doi.org/10.1038/5976

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AU - Marra, Marco

AU - Hillier, La Deana

AU - Kucaba, Tamara

AU - Allen, Melissa

AU - Barstead, Robert

AU - Beck, Catherine

AU - Blistain, Angela

AU - Bonaldo, Maria

AU - Bowers, Yvette

AU - Bowles, Louise

AU - Cardenas, Marco

AU - Chamberlain, Ann

AU - Chappell, Julie

AU - Clifton, Sandra

AU - Favello, Anthony

AU - Geisel, Steve

AU - Gibbons, Marilyn

AU - Harvey, Njata

AU - Hill, Francesca

AU - Jackson, Yolanda

AU - Kohn, Sophie

AU - Lennon, Greg

AU - Mardis, Elaine

AU - Martin, John

AU - Mila, Lee Anne

AU - McCann, Rhonda

AU - Morales, Richard

AU - Pape, Deana

AU - Person, Barry

AU - Prange, Christa

AU - Ritter, Erika

AU - Soares, Marcelo

AU - Schurk, Rebecca

AU - Shin, Tanya

AU - Steptoe, Michele

AU - Swaller, Timothy

AU - Theising, Brenda

AU - Underwood, Karen

AU - Wylie, Todd

AU - Yount, Tamara

AU - Wilson, Richard

AU - Waterston, Robert

N1 - Funding Information: We thank all investigators who have donated libraries for sequencing; S. Tilghman for scientific guidance; S. Chissoe and S. Gorski for comments on the manuscript and useful discussion; G. Schuler, C. Tolstoshev and others at NCBI for assistance with databases; and the staff at Washington University Genome Center for technical support. Work by C.P. and G.L. was supported by the U.S. DOE under contract W-7405-Eng-48 to LLNL. Work at Washington University was funded by a grant from Howard Hughes Medical Institute.

PY - 1999/2

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N2 - The laboratory mouse is the premier model system for studies of mammalian development due to the powerful classical genetic analysis possible (see also the Jackson Laboratory web site, http://www.jax.org/) and the ever- expanding collection of molecular tools. To enhance the utility of the mouse system, we initiated a program to generate a large database of expressed sequence tags (ESTs) that can provide rapid access to genes. Of particular significance was the possibility that cDNA libraries could be prepared from very early stages of development, a situation unrealized in human EST projects. We report here the development of a comprehensive database of ESTs for the mouse. The project, initiated in March 1996, has focused on 5' end sequences from directionally cloned, oligo-dT primed cDNA libraries. As of 23 October 1998, 352,040 sequences had been generated, annotated and deposited in dbEST, where they comprised 93% of the total ESTs available for mouse. EST data are versatile and have been applied to gene identification, comparative sequence analysis, comparative gene mapping and candidate disease gene identification, genome sequence annotation, microarray development and the development of gene-based map resources.

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An encyclopedia of mouse genes

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