An encyclopedia of mouse genes

Marco Marra, La Deana Hillier, Tamara Kucaba, Melissa Allen, Robert Barstead, Catherine Beck, Angela Blistain, Maria Bonaldo, Yvette Bowers, Louise Bowles, Marco Cardenas, Ann Chamberlain, Julie Chappell, Sandra Clifton, Anthony Favello, Steve Geisel, Marilyn Gibbons, Njata Harvey, Francesca Hill, Yolanda JacksonSophie Kohn, Greg Lennon, Elaine Mardis, John Martin, Lee Anne Mila, Rhonda McCann, Richard Morales, Deana Pape, Barry Person, Christa Prange, Erika Ritter, Marcelo Soares, Rebecca Schurk, Tanya Shin, Michele Steptoe, Timothy Swaller, Brenda Theising, Karen Underwood, Todd Wylie, Tamara Yount, Richard Wilson, Robert Waterston

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


The laboratory mouse is the premier model system for studies of mammalian development due to the powerful classical genetic analysis possible (see also the Jackson Laboratory web site, and the ever- expanding collection of molecular tools. To enhance the utility of the mouse system, we initiated a program to generate a large database of expressed sequence tags (ESTs) that can provide rapid access to genes. Of particular significance was the possibility that cDNA libraries could be prepared from very early stages of development, a situation unrealized in human EST projects. We report here the development of a comprehensive database of ESTs for the mouse. The project, initiated in March 1996, has focused on 5' end sequences from directionally cloned, oligo-dT primed cDNA libraries. As of 23 October 1998, 352,040 sequences had been generated, annotated and deposited in dbEST, where they comprised 93% of the total ESTs available for mouse. EST data are versatile and have been applied to gene identification, comparative sequence analysis, comparative gene mapping and candidate disease gene identification, genome sequence annotation, microarray development and the development of gene-based map resources.

Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalNature Genetics
Issue number2
StatePublished - Feb 1999


Dive into the research topics of 'An encyclopedia of mouse genes'. Together they form a unique fingerprint.

Cite this