An Electrically Compensated Trap Designed to Eighth Order for FT-ICR Mass Spectrometry

Adam M. Brustkern, Don L. Rempel, Michael L. Gross

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


We present the design, guided by theory to eighth order, and the first evaluation of a Fourier transform ion cyclotron resonance (FT-ICR) compensated trap. The purpose of the new trap is to reduce effects of the nonlinear components of the trapping electric field; those nonliner components introduce variations in the cyclotron frequency of an ion depending on its spatial position (its cyclotron and trapping mode amplitudes). This frequency spread leads to decreased mass resolving power and signal-to-noise. The reduction of the spread of cyclotron frequencies, as explicitly modeled in theory, serves as the basis for our design. The compensated trap shows improved signal-to-noise and at least a threefold increase in mass resolving power compared to the uncompensated trap at the same trapping voltage. Resolving powers (FWHH) as high as 1.7 × 107 for the [M + H]+ of vasopressin at m/z 1084.5 in a 7.0-tesla induction can be obtained when using trap compensation.

Original languageEnglish
Pages (from-to)1281-1285
Number of pages5
JournalJournal of the American Society for Mass Spectrometry
Issue number9
StatePublished - Sep 2008


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