TY - JOUR
T1 - An Electrically Compensated Trap Designed to Eighth Order for FT-ICR Mass Spectrometry
AU - Brustkern, Adam M.
AU - Rempel, Don L.
AU - Gross, Michael L.
N1 - Funding Information:
The authors acknowledge support for this research by a grant from the National Centers for Research Resources of the NIH (grant 2P41RR000954). The authors thank Robert McIver for his help in the construction and installation of the compensated trap.
PY - 2008/9
Y1 - 2008/9
N2 - We present the design, guided by theory to eighth order, and the first evaluation of a Fourier transform ion cyclotron resonance (FT-ICR) compensated trap. The purpose of the new trap is to reduce effects of the nonlinear components of the trapping electric field; those nonliner components introduce variations in the cyclotron frequency of an ion depending on its spatial position (its cyclotron and trapping mode amplitudes). This frequency spread leads to decreased mass resolving power and signal-to-noise. The reduction of the spread of cyclotron frequencies, as explicitly modeled in theory, serves as the basis for our design. The compensated trap shows improved signal-to-noise and at least a threefold increase in mass resolving power compared to the uncompensated trap at the same trapping voltage. Resolving powers (FWHH) as high as 1.7 × 107 for the [M + H]+ of vasopressin at m/z 1084.5 in a 7.0-tesla induction can be obtained when using trap compensation.
AB - We present the design, guided by theory to eighth order, and the first evaluation of a Fourier transform ion cyclotron resonance (FT-ICR) compensated trap. The purpose of the new trap is to reduce effects of the nonlinear components of the trapping electric field; those nonliner components introduce variations in the cyclotron frequency of an ion depending on its spatial position (its cyclotron and trapping mode amplitudes). This frequency spread leads to decreased mass resolving power and signal-to-noise. The reduction of the spread of cyclotron frequencies, as explicitly modeled in theory, serves as the basis for our design. The compensated trap shows improved signal-to-noise and at least a threefold increase in mass resolving power compared to the uncompensated trap at the same trapping voltage. Resolving powers (FWHH) as high as 1.7 × 107 for the [M + H]+ of vasopressin at m/z 1084.5 in a 7.0-tesla induction can be obtained when using trap compensation.
UR - http://www.scopus.com/inward/record.url?scp=50849142876&partnerID=8YFLogxK
U2 - 10.1016/j.jasms.2008.05.016
DO - 10.1016/j.jasms.2008.05.016
M3 - Article
C2 - 18599306
AN - SCOPUS:50849142876
SN - 1044-0305
VL - 19
SP - 1281
EP - 1285
JO - Journal of the American Society for Mass Spectrometry
JF - Journal of the American Society for Mass Spectrometry
IS - 9
ER -