An early investigation of ytterbium nanocolloids for selective and quantitative "multicolor" spectral CT imaging

Dipanjan Pan, Carsten O. Schirra, Angana Senpan, Anne H. Schmieder, Allen J. Stacy, Ewald Roessl, Axel Thran, Samuel A. Wickline, Roland Proska, Gregory M. Lanza

Research output: Contribution to journalArticle

86 Scopus citations

Abstract

We report a novel molecular imaging agent based on ytterbium designed for use with spectral "multicolor" computed tomography (CT). Spectral CT or multicolored CT provides all of the benefits of traditional CT, such as rapid tomographic X-ray imaging, but in addition, it simultaneously discriminates metal-rich contrast agents based on the elements unique X-ray K-edge energy signature. Our synthetic approach involved the use of organically soluble Yb(III) complex to produce nanocolloids of Yb of noncrystalline nature incorporating a high density of Yb (>500K/nanoparticle) into a stable metal particle. The resultant particles are constrained to vasculature (∼200 nm) and are highly selective for binding fibrin in the ruptured atherosclerotic plaque. Nanoparticles exhibited excellent signal sensitivity, and the spectral CT technique uniquely discriminates the K-edge signal (60 keV) of Yb from calcium (bones). Bioelimination and preliminary biodistribution reflected the overall safety and defined clearance of these particles in a rodent model.

Original languageEnglish
Pages (from-to)3364-3370
Number of pages7
JournalACS nano
Volume6
Issue number4
DOIs
StatePublished - Apr 24 2012

Keywords

  • contrast agent
  • multicolor imaging
  • nanoparticle
  • spectral CT imaging
  • thrombus
  • ytterbium

Fingerprint Dive into the research topics of 'An early investigation of ytterbium nanocolloids for selective and quantitative "multicolor" spectral CT imaging'. Together they form a unique fingerprint.

  • Cite this

    Pan, D., Schirra, C. O., Senpan, A., Schmieder, A. H., Stacy, A. J., Roessl, E., Thran, A., Wickline, S. A., Proska, R., & Lanza, G. M. (2012). An early investigation of ytterbium nanocolloids for selective and quantitative "multicolor" spectral CT imaging. ACS nano, 6(4), 3364-3370. https://doi.org/10.1021/nn300392x