An application of smoothing splines for molecular imaging of tumors using an improved calculation of a limiting form of Renyi entropy

M. S. Hughes; J. N. Marsh; K. D. Wallace; G. M. Lanza; S. A. Wickline; J. E. McCarthy; M. V. Wickerhauser; B. N. Maurizi

doi:10.1109/ULTSYM.2010.5935961

An application of smoothing splines for molecular imaging of tumors using an improved calculation of a limiting form of Renyi entropy

M. S. Hughes, J. N. Marsh, K. D. Wallace, G. M. Lanza, S. A. Wickline, J. E. McCarthy, M. V. Wickerhauser, B. N. Maurizi

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

In several investigations of molecular imaging of angiogenic neovasculature using a targeted contrast agent, Renyi entropy (I_f(r)) and a limiting form of Renyi entropy (I_f,) exhibited significantly more sensitivity to subtle changes in scattering architecture than energy-based methods. Many of these studies required the fitting of a cubic spline to backscattered waveforms prior to calculation of entropy (either I_f(r) or I_f,). In this study it is shown that the robustness of I _f, may be improved by using a smoothing spline. Results are presented showing the impact of different smoothing parameters. In addition, if smoothing is preceded by lowpass filtering of the waveforms, further improvements may be obtained.

Original language	English
Title of host publication	2010 IEEE International Ultrasonics Symposium, IUS 2010
Pages	45-48
Number of pages	4
DOIs	https://doi.org/10.1109/ULTSYM.2010.5935961
State	Published - 2010
Event	2010 IEEE International Ultrasonics Symposium, IUS 2010 - San Diego, CA, United States Duration: Oct 11 2010 → Oct 14 2010

Publication series

Name	Proceedings - IEEE Ultrasonics Symposium
ISSN (Print)	1051-0117

Conference

Conference	2010 IEEE International Ultrasonics Symposium, IUS 2010
Country/Territory	United States
City	San Diego, CA
Period	10/11/10 → 10/14/10

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10.1109/ULTSYM.2010.5935961

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Hughes, M. S., Marsh, J. N., Wallace, K. D., Lanza, G. M., Wickline, S. A., McCarthy, J. E., Wickerhauser, M. V., & Maurizi, B. N. (2010). An application of smoothing splines for molecular imaging of tumors using an improved calculation of a limiting form of Renyi entropy. In 2010 IEEE International Ultrasonics Symposium, IUS 2010 (pp. 45-48). Article 5935961 (Proceedings - IEEE Ultrasonics Symposium). https://doi.org/10.1109/ULTSYM.2010.5935961

@inproceedings{915f8d58af824b9caa344d5c4e943724,

title = "An application of smoothing splines for molecular imaging of tumors using an improved calculation of a limiting form of Renyi entropy",

abstract = "In several investigations of molecular imaging of angiogenic neovasculature using a targeted contrast agent, Renyi entropy (If(r)) and a limiting form of Renyi entropy (If,) exhibited significantly more sensitivity to subtle changes in scattering architecture than energy-based methods. Many of these studies required the fitting of a cubic spline to backscattered waveforms prior to calculation of entropy (either If(r) or If,). In this study it is shown that the robustness of I f, may be improved by using a smoothing spline. Results are presented showing the impact of different smoothing parameters. In addition, if smoothing is preceded by lowpass filtering of the waveforms, further improvements may be obtained.",

author = "Hughes, {M. S.} and Marsh, {J. N.} and Wallace, {K. D.} and Lanza, {G. M.} and Wickline, {S. A.} and McCarthy, {J. E.} and Wickerhauser, {M. V.} and Maurizi, {B. N.}",

year = "2010",

doi = "10.1109/ULTSYM.2010.5935961",

language = "English",

isbn = "9781457703829",

series = "Proceedings - IEEE Ultrasonics Symposium",

pages = "45--48",

booktitle = "2010 IEEE International Ultrasonics Symposium, IUS 2010",

note = "2010 IEEE International Ultrasonics Symposium, IUS 2010 ; Conference date: 11-10-2010 Through 14-10-2010",

}

Hughes, MS, Marsh, JN, Wallace, KD, Lanza, GM, Wickline, SA, McCarthy, JE, Wickerhauser, MV & Maurizi, BN 2010, An application of smoothing splines for molecular imaging of tumors using an improved calculation of a limiting form of Renyi entropy. in 2010 IEEE International Ultrasonics Symposium, IUS 2010., 5935961, Proceedings - IEEE Ultrasonics Symposium, pp. 45-48, 2010 IEEE International Ultrasonics Symposium, IUS 2010, San Diego, CA, United States, 10/11/10. https://doi.org/10.1109/ULTSYM.2010.5935961

An application of smoothing splines for molecular imaging of tumors using an improved calculation of a limiting form of Renyi entropy. / Hughes, M. S.; Marsh, J. N.; Wallace, K. D. et al.
2010 IEEE International Ultrasonics Symposium, IUS 2010. 2010. p. 45-48 5935961 (Proceedings - IEEE Ultrasonics Symposium).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Wickline, S. A.

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AB - In several investigations of molecular imaging of angiogenic neovasculature using a targeted contrast agent, Renyi entropy (If(r)) and a limiting form of Renyi entropy (If,) exhibited significantly more sensitivity to subtle changes in scattering architecture than energy-based methods. Many of these studies required the fitting of a cubic spline to backscattered waveforms prior to calculation of entropy (either If(r) or If,). In this study it is shown that the robustness of I f, may be improved by using a smoothing spline. Results are presented showing the impact of different smoothing parameters. In addition, if smoothing is preceded by lowpass filtering of the waveforms, further improvements may be obtained.

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Hughes MS, Marsh JN, Wallace KD, Lanza GM, Wickline SA, McCarthy JE et al. An application of smoothing splines for molecular imaging of tumors using an improved calculation of a limiting form of Renyi entropy. In 2010 IEEE International Ultrasonics Symposium, IUS 2010. 2010. p. 45-48. 5935961. (Proceedings - IEEE Ultrasonics Symposium). doi: 10.1109/ULTSYM.2010.5935961

An application of smoothing splines for molecular imaging of tumors using an improved calculation of a limiting form of Renyi entropy

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