An application of smoothing splines for molecular imaging of tumors using an improved calculation of a limiting form of Renyi entropy

M. S. Hughes, J. N. Marsh, K. D. Wallace, G. M. Lanza, S. A. Wickline, J. E. McCarthy, M. V. Wickerhauser, B. N. Maurizi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In several investigations of molecular imaging of angiogenic neovasculature using a targeted contrast agent, Renyi entropy (If(r)) and a limiting form of Renyi entropy (If,) exhibited significantly more sensitivity to subtle changes in scattering architecture than energy-based methods. Many of these studies required the fitting of a cubic spline to backscattered waveforms prior to calculation of entropy (either If(r) or If,). In this study it is shown that the robustness of I f, may be improved by using a smoothing spline. Results are presented showing the impact of different smoothing parameters. In addition, if smoothing is preceded by lowpass filtering of the waveforms, further improvements may be obtained.

Original languageEnglish
Title of host publication2010 IEEE International Ultrasonics Symposium, IUS 2010
Pages45-48
Number of pages4
DOIs
StatePublished - Dec 1 2010
Event2010 IEEE International Ultrasonics Symposium, IUS 2010 - San Diego, CA, United States
Duration: Oct 11 2010Oct 14 2010

Publication series

NameProceedings - IEEE Ultrasonics Symposium
ISSN (Print)1051-0117

Conference

Conference2010 IEEE International Ultrasonics Symposium, IUS 2010
CountryUnited States
CitySan Diego, CA
Period10/11/1010/14/10

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    Hughes, M. S., Marsh, J. N., Wallace, K. D., Lanza, G. M., Wickline, S. A., McCarthy, J. E., Wickerhauser, M. V., & Maurizi, B. N. (2010). An application of smoothing splines for molecular imaging of tumors using an improved calculation of a limiting form of Renyi entropy. In 2010 IEEE International Ultrasonics Symposium, IUS 2010 (pp. 45-48). [5935961] (Proceedings - IEEE Ultrasonics Symposium). https://doi.org/10.1109/ULTSYM.2010.5935961