An anxiogenic benzodiazepine receptor ligand induces learned helplessness

Robert C. Drugan; Steven F. Maier; Phil Skolnick; Steven M. Paul; Jacqueline N. Crawley

doi:10.1016/0014-2999(85)90096-2

An anxiogenic benzodiazepine receptor ligand induces learned helplessness

Robert C. Drugan, Steven F. Maier, Phil Skolnick, Steven M. Paul, Jacqueline N. Crawley

Washington University School of Medicine

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

Rats treated with the anxiogenic β-carboline, N-methyl-β-carboline-3-carboxamide (FG-7142), failed to acquire an excape response 24 h after treatment. Administration of FG-7142 resulted in a behavioral effect equivalent to a session of inescapable tailshock in this paradigm of learned helplessness. Pretreatment of rats with the selective benzodiazepine receptor antagonist Ro15-1788 blocked the development of learned helplessness elicited by FG-7142. These findings suggest that 'anxiety' may be a major factor in the development of learned helplessness.

Original language	English
Pages (from-to)	453-457
Number of pages	5
Journal	European Journal of Pharmacology
Volume	113
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(85)90096-2
State	Published - Jul 31 1985

Keywords

Antagonist
Anxiety
Depression
β-Carboline

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10.1016/0014-2999(85)90096-2

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title = "An anxiogenic benzodiazepine receptor ligand induces learned helplessness",

abstract = "Rats treated with the anxiogenic β-carboline, N-methyl-β-carboline-3-carboxamide (FG-7142), failed to acquire an excape response 24 h after treatment. Administration of FG-7142 resulted in a behavioral effect equivalent to a session of inescapable tailshock in this paradigm of learned helplessness. Pretreatment of rats with the selective benzodiazepine receptor antagonist Ro15-1788 blocked the development of learned helplessness elicited by FG-7142. These findings suggest that 'anxiety' may be a major factor in the development of learned helplessness.",

keywords = "Antagonist, Anxiety, Depression, β-Carboline",

author = "Drugan, {Robert C.} and Maier, {Steven F.} and Phil Skolnick and Paul, {Steven M.} and Crawley, {Jacqueline N.}",

note = "Funding Information: FG-7142 was kindly supplied by Dr. Claus Braestrup, A/S Ferrosan Research Division. Ro15-1788 was a research gift from Hoffman-La Roche, Inc. This research was supported in part by NSF Grant BNS-82-0944~ RSDA MH00314, and BRSG Grant RR07013 to Steven F. Maier. Robert C. Drugan is presently a member of the Unit on Behavioral Neuropharmacology, Clinical Neuroscience Branch, NIMH.",

year = "1985",

month = jul,

day = "31",

doi = "10.1016/0014-2999(85)90096-2",

language = "English",

volume = "113",

pages = "453--457",

journal = "European Journal of Pharmacology",

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T1 - An anxiogenic benzodiazepine receptor ligand induces learned helplessness

AU - Drugan, Robert C.

AU - Maier, Steven F.

AU - Skolnick, Phil

AU - Paul, Steven M.

AU - Crawley, Jacqueline N.

N1 - Funding Information: FG-7142 was kindly supplied by Dr. Claus Braestrup, A/S Ferrosan Research Division. Ro15-1788 was a research gift from Hoffman-La Roche, Inc. This research was supported in part by NSF Grant BNS-82-0944~ RSDA MH00314, and BRSG Grant RR07013 to Steven F. Maier. Robert C. Drugan is presently a member of the Unit on Behavioral Neuropharmacology, Clinical Neuroscience Branch, NIMH.

PY - 1985/7/31

Y1 - 1985/7/31

N2 - Rats treated with the anxiogenic β-carboline, N-methyl-β-carboline-3-carboxamide (FG-7142), failed to acquire an excape response 24 h after treatment. Administration of FG-7142 resulted in a behavioral effect equivalent to a session of inescapable tailshock in this paradigm of learned helplessness. Pretreatment of rats with the selective benzodiazepine receptor antagonist Ro15-1788 blocked the development of learned helplessness elicited by FG-7142. These findings suggest that 'anxiety' may be a major factor in the development of learned helplessness.

AB - Rats treated with the anxiogenic β-carboline, N-methyl-β-carboline-3-carboxamide (FG-7142), failed to acquire an excape response 24 h after treatment. Administration of FG-7142 resulted in a behavioral effect equivalent to a session of inescapable tailshock in this paradigm of learned helplessness. Pretreatment of rats with the selective benzodiazepine receptor antagonist Ro15-1788 blocked the development of learned helplessness elicited by FG-7142. These findings suggest that 'anxiety' may be a major factor in the development of learned helplessness.

KW - Antagonist

KW - Anxiety

KW - Depression

KW - β-Carboline

UR - http://www.scopus.com/inward/record.url?scp=0022205150&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(85)90096-2

DO - 10.1016/0014-2999(85)90096-2

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VL - 113

SP - 453

EP - 457

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 3

ER -

An anxiogenic benzodiazepine receptor ligand induces learned helplessness

Abstract

Keywords

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