TY - JOUR
T1 - An analysis of within-subject and population level risk related to substance use and mental health outcomes among adolescents in the PATH study
AU - Li, Xiao
AU - Borodovsky, Jacob T.
AU - Kasson, Erin M.
AU - Fentem, Andrea
AU - Cavazos-Rehg, Patricia A.
N1 - Funding Information:
Financial support for this study was provided by the National Institutes of Health ( NIH K02 DA043657 ) (PI: Patricia A. Cavazos-Rehg) and the National Institute on Alcohol Abuse and Alcoholism ( NIAAA F32AA027941 ), (PI: Jacob T. Borodovsky). The content of this paper is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the National Institute on Alcohol Abuse and Alcoholism.
Funding Information:
Financial support for this study was provided by the National Institutes of Health (NIH), Grant K02 DA043657 (PI: Patricia Cavazos-Rehg) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA), Grant F32AA027941 (PI: Jacob Borodovsky). No funding sources had any role in the study design, collection, analysis or interpretation of the data, writing the manuscript, or the decision to submit the paper for publication.
Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Introduction: The objective of this study was to understand how adolescent substance use patterns may lead to negative mental health outcomes. Methods: Data from adolescents (12–17 years old at baseline, Wave 1) who participated in the first 3 waves of the Population Assessment of Health and Tobacco (PATH) study were used. Self-reported data on past 30-day substance use and internalizing/externalizing problems were used to conduct within-subject (fixed-effects model) and population-averaged (GEE model) analyses. Results: In both within-subject and between-subject analyses, the use of other illicit drugs (e.g., opioids, cocaine, prescription drugs for non-medical use) was positively associated with internalizing problems (within-subject estimate, AOR: 1.65, 95 % CI = 1.36–2.01; between-subject estimate, AOR: 1.53, 95 % CI = 1.32–1.78) and alcohol use was positively associated with externalizing problems (within-subject estimate, AOR: 1.66, 95 % CI = 1.43–1.93; between-subject estimate, AOR: 1.67, 95 % CI = 1.48–1.89). Additionally, within-subject analysis suggested that alcohol, marijuana, and other illicit drugs were associated with increased odds of comorbid internalizing and externalizing problems (ranging from marijuana, AOR: 1.18, - alcohol, AOR: 1.58). Discussion: Using within-subject and between-subject comparisons, this study demonstrated associations between adolescent substance use and internalizing and externalizing problems. Results suggest not only the need for individual level assessment and early intervention, but also the development and implementation of public health policy aimed at preventing or mitigating the negative effects of substance use in adolescence to promote improved mental health outcomes for this at-risk group.
AB - Introduction: The objective of this study was to understand how adolescent substance use patterns may lead to negative mental health outcomes. Methods: Data from adolescents (12–17 years old at baseline, Wave 1) who participated in the first 3 waves of the Population Assessment of Health and Tobacco (PATH) study were used. Self-reported data on past 30-day substance use and internalizing/externalizing problems were used to conduct within-subject (fixed-effects model) and population-averaged (GEE model) analyses. Results: In both within-subject and between-subject analyses, the use of other illicit drugs (e.g., opioids, cocaine, prescription drugs for non-medical use) was positively associated with internalizing problems (within-subject estimate, AOR: 1.65, 95 % CI = 1.36–2.01; between-subject estimate, AOR: 1.53, 95 % CI = 1.32–1.78) and alcohol use was positively associated with externalizing problems (within-subject estimate, AOR: 1.66, 95 % CI = 1.43–1.93; between-subject estimate, AOR: 1.67, 95 % CI = 1.48–1.89). Additionally, within-subject analysis suggested that alcohol, marijuana, and other illicit drugs were associated with increased odds of comorbid internalizing and externalizing problems (ranging from marijuana, AOR: 1.18, - alcohol, AOR: 1.58). Discussion: Using within-subject and between-subject comparisons, this study demonstrated associations between adolescent substance use and internalizing and externalizing problems. Results suggest not only the need for individual level assessment and early intervention, but also the development and implementation of public health policy aimed at preventing or mitigating the negative effects of substance use in adolescence to promote improved mental health outcomes for this at-risk group.
KW - Externalizing problems
KW - Internalizing problems
KW - Mental health
KW - PATH
KW - Substance use
UR - http://www.scopus.com/inward/record.url?scp=85096372607&partnerID=8YFLogxK
U2 - 10.1016/j.drugalcdep.2020.108385
DO - 10.1016/j.drugalcdep.2020.108385
M3 - Article
C2 - 33168340
AN - SCOPUS:85096372607
SN - 0376-8716
VL - 218
JO - Drug and Alcohol Dependence
JF - Drug and Alcohol Dependence
M1 - 108385
ER -