An analysis of FDA-approved drugs for infectious disease: HIV/AIDS drugs

Michael S. Kinch, Eric Patridge

Research output: Contribution to journalShort surveypeer-review

50 Scopus citations


HIV/AIDS is one of the worst pandemics in history. According to the World Health Organization, 26 million people have died since 1981 - 1.6 million in 2012 alone. The dramatic rise in HIV/AIDS mobilized a swift and impressive coordination among governmental, academic and private sector organizations to identify the virus and develop new treatments. Herein, we assess the arsenal of 28 new molecular entities (NMEs) targeting HIV/AIDS. These data demonstrate that the first approval of zidovudine presaged an expansion of the antiviral repertoire over the following years. Whereas the rate of HIV/AIDS NMEs is rapidly declining, so is the number of organizations developing NMEs. We speculate that decisions to abandon further research reflect, in part, growing costs and time required for development.

Original languageEnglish
Pages (from-to)1510-1513
Number of pages4
JournalDrug Discovery Today
Issue number10
StatePublished - Oct 2014


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