In this report an analysis of cochlear response harmonics is developed to derive a mathematical function to estimate the gross mechanics involved in the in vivo transfer of acoustic sound into neural excitation (fTr). In a simulation it is shown that the harmonic distortion from a nonlinear system can be used to estimate the nonlinearity, supporting the next phase of the experiment: Applying the harmonic analysis to physiologic measurements to derive estimates of the unknown, in vivo fTr. From gerbil ears, estimates of fTr were derived from cochlear response measurements made with an electrode at the round window niche from 85 Hz tone bursts. Estimates of fTr before and after inducing auditory neuropathy - loss of auditory nerve responses with preserved hair cell responses from neurotoxic treatment with ouabain - showed that the neural excitation from low-frequency tones contributes to the magnitude of fTr but not the sigmoidal, saturating, nonlinear morphology.
|Number of pages||7|
|Journal||Journal of the Acoustical Society of America|
|State||Published - Nov 1 2015|