An analog of myristic acid with selective toxicity for African trypanosomes

Tamara Brent, Jayne Raper, Laurence U. Buxbaum, Steven P. Adams, Jeffrey Gordon, Gerald W. Hart, Paul T. Englund

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

Trypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, evades the host immune response through the process of antigenic variation. The variant antigen, known as the variant surface glycoprotein (VSG), is anchored to the cell surface by a glycosyl phosphatidylinositol (GPI) structure that contains myristate (n-tetradecanoate) as its only fatty acid component. The utilization of heteroatom-containing analogs of myristate was studied both in a cell-free system and in vivo. Results indicated that the specificity of fatty acid incorporation depends on chain length rather than on hydrophobicity. One analog, 10-(propoxy)decanoic acid, was highly toxic to trypanosomes in culture although it is nontoxic to mammalian cells.

Original languageEnglish
Pages (from-to)1851-1854
Number of pages4
JournalScience
Volume252
Issue number5014
DOIs
StatePublished - 1991

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