An adaptive spike-timing-dependent plasticity rule

Jesper Tegnér, Ádám Kepecs

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


We examine the conditions under which spike-timing-dependent plasticity (STDP) normalizes post-synaptic firing rates. Our simulations show that the rate normalization property of STDP is fragile and small changes in the LTD/LTP ratio or pre-synaptic input rates can lead to high firing rates. We propose an adaptive scheme to dynamically control the LTP/LTD ratio. The biophysics of synapses lead us to suggest a control mechanism using action potential-induced calcium influx, a known mediator of synaptic plasticity. This adaptive STDP rule is shown to stabilize the post-synaptic firing rates under a variety of perturbations.

Original languageEnglish
Pages (from-to)189-194
Number of pages6
StatePublished - 2002


  • Hebbian
  • Homeostatic mechanisms
  • Learning
  • Spike correlations


Dive into the research topics of 'An adaptive spike-timing-dependent plasticity rule'. Together they form a unique fingerprint.

Cite this