An acoustofluidic sputum liquefier

Po Hsun Huang; Liqiang Ren; Nitesh Nama; Sixing Li; Peng Li; Xianglan Yao; Rosemarie A. Cuento; Cheng Hsin Wei; Yuchao Chen; Yuliang Xie; Ahmad Ahsan Nawaz; Yael G. Alevy; Michael J. Holtzman; J. Philip McCoy; Stewart J. Levine; Tony Jun Huang

doi:10.1039/c5lc00539f

An acoustofluidic sputum liquefier

Po Hsun Huang, Liqiang Ren, Nitesh Nama, Sixing Li, Peng Li, Xianglan Yao, Rosemarie A. Cuento, Cheng Hsin Wei, Yuchao Chen, Yuliang Xie, Ahmad Ahsan Nawaz, Yael G. Alevy, Michael J. Holtzman, J. Philip McCoy, Stewart J. Levine, Tony Jun Huang

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

We demonstrate the first microfluidic-based on-chip liquefaction device for human sputum samples. Our device is based on an acoustofluidic micromixer using oscillating sharp edges. This acoustofluidic sputum liquefier can effectively and uniformly liquefy sputum samples at a throughput of 30 μL min^-1. Cell viability and integrity are maintained during the sputum liquefaction process. Our acoustofluidic sputum liquefier can be conveniently integrated with other microfluidic units to enable automated on-chip sputum processing and analysis.

Original language	English
Pages (from-to)	3125-3131
Number of pages	7
Journal	Lab on a Chip
Volume	15
Issue number	15
DOIs	https://doi.org/10.1039/c5lc00539f
State	Published - Jun 8 2015

Access to Document

10.1039/c5lc00539f

Cite this

@article{e2a357f66cd045deb0d39cd84cea3c7f,

title = "An acoustofluidic sputum liquefier",

abstract = "We demonstrate the first microfluidic-based on-chip liquefaction device for human sputum samples. Our device is based on an acoustofluidic micromixer using oscillating sharp edges. This acoustofluidic sputum liquefier can effectively and uniformly liquefy sputum samples at a throughput of 30 μL min-1. Cell viability and integrity are maintained during the sputum liquefaction process. Our acoustofluidic sputum liquefier can be conveniently integrated with other microfluidic units to enable automated on-chip sputum processing and analysis.",

author = "Huang, {Po Hsun} and Liqiang Ren and Nitesh Nama and Sixing Li and Peng Li and Xianglan Yao and Cuento, {Rosemarie A.} and Wei, {Cheng Hsin} and Yuchao Chen and Yuliang Xie and Nawaz, {Ahmad Ahsan} and Alevy, {Yael G.} and Holtzman, {Michael J.} and McCoy, {J. Philip} and Levine, {Stewart J.} and Huang, {Tony Jun}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2015.",

year = "2015",

month = jun,

day = "8",

doi = "10.1039/c5lc00539f",

language = "English",

volume = "15",

pages = "3125--3131",

journal = "Lab on a Chip",

issn = "1473-0197",

number = "15",

}

TY - JOUR

T1 - An acoustofluidic sputum liquefier

AU - Huang, Po Hsun

AU - Ren, Liqiang

AU - Nama, Nitesh

AU - Li, Sixing

AU - Li, Peng

AU - Yao, Xianglan

AU - Cuento, Rosemarie A.

AU - Wei, Cheng Hsin

AU - Chen, Yuchao

AU - Xie, Yuliang

AU - Nawaz, Ahmad Ahsan

AU - Alevy, Yael G.

AU - Holtzman, Michael J.

AU - McCoy, J. Philip

AU - Levine, Stewart J.

AU - Huang, Tony Jun

PY - 2015/6/8

Y1 - 2015/6/8

N2 - We demonstrate the first microfluidic-based on-chip liquefaction device for human sputum samples. Our device is based on an acoustofluidic micromixer using oscillating sharp edges. This acoustofluidic sputum liquefier can effectively and uniformly liquefy sputum samples at a throughput of 30 μL min-1. Cell viability and integrity are maintained during the sputum liquefaction process. Our acoustofluidic sputum liquefier can be conveniently integrated with other microfluidic units to enable automated on-chip sputum processing and analysis.

AB - We demonstrate the first microfluidic-based on-chip liquefaction device for human sputum samples. Our device is based on an acoustofluidic micromixer using oscillating sharp edges. This acoustofluidic sputum liquefier can effectively and uniformly liquefy sputum samples at a throughput of 30 μL min-1. Cell viability and integrity are maintained during the sputum liquefaction process. Our acoustofluidic sputum liquefier can be conveniently integrated with other microfluidic units to enable automated on-chip sputum processing and analysis.

UR - http://www.scopus.com/inward/record.url?scp=84942318761&partnerID=8YFLogxK

U2 - 10.1039/c5lc00539f

DO - 10.1039/c5lc00539f

M3 - Article

C2 - 26082346

AN - SCOPUS:84942318761

SN - 1473-0197

VL - 15

SP - 3125

EP - 3131

JO - Lab on a Chip

JF - Lab on a Chip

IS - 15

ER -

An acoustofluidic sputum liquefier

Abstract

Access to Document

Other files and links

Fingerprint

Cite this