An 11-month-old with anti-glomerular basement membrane disease

Steven A. Bigler, Wilson M. Parry, Douglas S. Fitzwater, Radhakrishna Baliga

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6 Scopus citations


Anti-glomerular basement membrane antibody disease is an autoimmune disease that has rarely been described in children, and no cases have previously been described in a patient younger than 2.5 years of age. We report an 11-month-old infant girl who developed anti-glomerular basement membrane disease and progressed to end-stage renal disease and eventual renal transplantation. Although it has been suggested that this disease does not occur in infants, the possibility of anti-glomerular basement membrane disease must be considered in the differential diagnosis of acute renal failure and glomerulonephritis in an infant. The characteristic linear pattern of immunofluorescent studies for Immunoglobulin (Ig) G is important in suggesting the diagnosis, which can be confirmed by serologic testing for antibody titers.

Original languageEnglish
Pages (from-to)710-712
Number of pages3
JournalAmerican Journal of Kidney Diseases
Issue number5
StatePublished - Nov 1997


  • Anti-glomerular basement membrane
  • GBM
  • Goodpasture's syndrome
  • Human
  • Infant
  • Kidney


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