Amyloid-β dynamics correlate with neurological status in the injured human brain

David L. Brody, Sandra Magnoni, Kate E. Schwetye, Michael Spinner, Thomas J. Esparza, Nino Stocchetti, Greg J. Zipfel, David M. Holtzman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The amyloid-β peptide (Aβ) plays a central pathophysiological role in Alzheimer's disease, but virtually nothing is known about the concentration and dynamics of this secreted peptide in the extracellular space of the human brain. We used intracerebral microdialysis to obtain serial brain interstitial fluid (ISF) samples in 18 patients who were undergoing invasive intracranial monitoring after acute brain injury. We found a strong positive correlation between changes in brain ISF Aβ levels and neurological status, and correlations with other cerebral physiological and metabolic abnormalities reflecting depressed neuronal function. Such dynamics fit well with the hypothesis that neuronal activity regulates extracellular Aβ concentration.

Original languageEnglish
Title of host publication3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009
DOIs
StatePublished - Dec 31 2009
Event3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009 - Beijing, China
Duration: Jun 11 2009Jun 13 2009

Publication series

Name3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009

Conference

Conference3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009
CountryChina
CityBeijing
Period06/11/0906/13/09

Keywords

  • Alzheimer disease
  • Amyloid beta
  • Microdialysis
  • Subarachnoid hemorrhage
  • Traumatic brain injury

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  • Cite this

    Brody, D. L., Magnoni, S., Schwetye, K. E., Spinner, M., Esparza, T. J., Stocchetti, N., Zipfel, G. J., & Holtzman, D. M. (2009). Amyloid-β dynamics correlate with neurological status in the injured human brain. In 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009 [5162305] (3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009). https://doi.org/10.1109/ICBBE.2009.5162305