Amyloid-β diurnal pattern: Possible role of sleep in Alzheimer's disease pathogenesis

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Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline that is a growing public health crisis with a prevalence projected to more than double in the next 20years. Sleep is frequently impaired in individuals with AD. Further, recent studies have linked numerous age-related sleep disturbances such as poor sleep efficiency and sleep apnea, to future risk of cognitive impairment. Aggregation of amyloid-β (Aβ) into extracellular plaques in the brain is a key step in AD pathogenesis and likely begins 20years before the onset of dementia. Aβ concentrations in both humans and mouse models show Aβ concentrations rise during wakefulness and fall during sleep, that is, an Aβ diurnal pattern. There is evidence in animal models that changes in sleep time alter Aβ deposition, suggesting that sleep may play a role in AD pathogenesis. A hypothetical model for the role of sleep and the Aβ diurnal pattern in AD pathogenesis is proposed.

Original languageEnglish
Pages (from-to)S29-S34
JournalNeurobiology of Aging
Volume35
Issue numberSUPPL.2
DOIs
StatePublished - Sep 2014

Keywords

  • Alzheimer's disease
  • Amyloid-β
  • Diurnal pattern
  • Sleep

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