Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome

Monika Grigorova; Elijah Mak; Stephanie S.G. Brown; Jessica Beresford-Webb; Young T. Hong; Tim D. Fryer; Jonathan P. Coles; Franklin I. Aigbirhio; Dana Tudorascu; Annie Cohen; Bradley T. Christian; Beau Ances; Benjamin L. Handen; Charles M. Laymon; William E. Klunk; Isabel C.H. Clare; Anthony J. Holland; Shahid H. Zaman

doi:10.1016/j.neurobiolaging.2022.07.003

Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome

Monika Grigorova, Elijah Mak, Stephanie S.G. Brown, Jessica Beresford-Webb, Young T. Hong, Tim D. Fryer, Jonathan P. Coles, Franklin I. Aigbirhio, Dana Tudorascu, Annie Cohen, Bradley T. Christian, Beau Ances, Benjamin L. Handen, Charles M. Laymon, William E. Klunk, Isabel C.H. Clare, Anthony J. Holland, Shahid H. Zaman

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8 Scopus citations

Abstract

This study investigates whether tau has (i) an independent effect from amyloid-β on changes in cognitive and functional performance and (ii) a synergistic relationship with amyloid-β in the exacerbation of decline in aging Down syndrome (DS). 105 participants with DS underwent baseline PET [¹⁸F]-AV1451 and PET [¹¹C]PiB scans to quantify tau deposition in Braak regions II-VI and the Striatum and amyloid-β status respectively. Linear Mixed Effects models were implemented to assess how tau and amyloid-β deposition are related to change over three time points. Tau was a significant independent predictor of cognitive and functional change. The three-way interaction between time, [¹¹C]PiB status and tau was significant in the models of episodic memory and visuospatial cognition. Baseline tau is a significant predictor of cognitive and functional decline, over and above the effect of amyloid-β status. Results suggest a synergistic relationship between amyloid-β status and tau as predictors of change in memory and visuospatial cognition.

Original language	English
Pages (from-to)	36-45
Number of pages	10
Journal	Neurobiology of Aging
Volume	119
DOIs	https://doi.org/10.1016/j.neurobiolaging.2022.07.003
State	Published - Nov 2022

Keywords

Alzheimer's disease
Amyloid-β
Down syndrome
PET [C]PiB
PET [F]-AV1451
Tau

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10.1016/j.neurobiolaging.2022.07.003

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Grigorova, M., Mak, E., Brown, S. S. G., Beresford-Webb, J., Hong, Y. T., Fryer, T. D., Coles, J. P., Aigbirhio, F. I., Tudorascu, D., Cohen, A., Christian, B. T., Ances, B., Handen, B. L., Laymon, C. M., Klunk, W. E., Clare, I. C. H., Holland, A. J., & Zaman, S. H. (2022). Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome. Neurobiology of Aging, 119, 36-45. https://doi.org/10.1016/j.neurobiolaging.2022.07.003

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title = "Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome",

abstract = "This study investigates whether tau has (i) an independent effect from amyloid-β on changes in cognitive and functional performance and (ii) a synergistic relationship with amyloid-β in the exacerbation of decline in aging Down syndrome (DS). 105 participants with DS underwent baseline PET [18F]-AV1451 and PET [11C]PiB scans to quantify tau deposition in Braak regions II-VI and the Striatum and amyloid-β status respectively. Linear Mixed Effects models were implemented to assess how tau and amyloid-β deposition are related to change over three time points. Tau was a significant independent predictor of cognitive and functional change. The three-way interaction between time, [11C]PiB status and tau was significant in the models of episodic memory and visuospatial cognition. Baseline tau is a significant predictor of cognitive and functional decline, over and above the effect of amyloid-β status. Results suggest a synergistic relationship between amyloid-β status and tau as predictors of change in memory and visuospatial cognition.",

keywords = "Alzheimer's disease, Amyloid-β, Down syndrome, PET [C]PiB, PET [F]-AV1451, Tau",

author = "Monika Grigorova and Elijah Mak and Brown, {Stephanie S.G.} and Jessica Beresford-Webb and Hong, {Young T.} and Fryer, {Tim D.} and Coles, {Jonathan P.} and Aigbirhio, {Franklin I.} and Dana Tudorascu and Annie Cohen and Christian, {Bradley T.} and Beau Ances and Handen, {Benjamin L.} and Laymon, {Charles M.} and Klunk, {William E.} and Clare, {Isabel C.H.} and Holland, {Anthony J.} and Zaman, {Shahid H.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = nov,

doi = "10.1016/j.neurobiolaging.2022.07.003",

language = "English",

volume = "119",

pages = "36--45",

journal = "Neurobiology of Aging",

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Grigorova, M, Mak, E, Brown, SSG, Beresford-Webb, J, Hong, YT, Fryer, TD, Coles, JP, Aigbirhio, FI, Tudorascu, D, Cohen, A, Christian, BT, Ances, B, Handen, BL, Laymon, CM, Klunk, WE, Clare, ICH, Holland, AJ & Zaman, SH 2022, 'Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome', Neurobiology of Aging, vol. 119, pp. 36-45. https://doi.org/10.1016/j.neurobiolaging.2022.07.003

TY - JOUR

T1 - Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome

AU - Grigorova, Monika

AU - Mak, Elijah

AU - Brown, Stephanie S.G.

AU - Beresford-Webb, Jessica

AU - Hong, Young T.

AU - Fryer, Tim D.

AU - Coles, Jonathan P.

AU - Aigbirhio, Franklin I.

AU - Tudorascu, Dana

AU - Cohen, Annie

AU - Christian, Bradley T.

AU - Ances, Beau

AU - Handen, Benjamin L.

AU - Laymon, Charles M.

AU - Klunk, William E.

AU - Clare, Isabel C.H.

AU - Holland, Anthony J.

AU - Zaman, Shahid H.

PY - 2022/11

Y1 - 2022/11

N2 - This study investigates whether tau has (i) an independent effect from amyloid-β on changes in cognitive and functional performance and (ii) a synergistic relationship with amyloid-β in the exacerbation of decline in aging Down syndrome (DS). 105 participants with DS underwent baseline PET [18F]-AV1451 and PET [11C]PiB scans to quantify tau deposition in Braak regions II-VI and the Striatum and amyloid-β status respectively. Linear Mixed Effects models were implemented to assess how tau and amyloid-β deposition are related to change over three time points. Tau was a significant independent predictor of cognitive and functional change. The three-way interaction between time, [11C]PiB status and tau was significant in the models of episodic memory and visuospatial cognition. Baseline tau is a significant predictor of cognitive and functional decline, over and above the effect of amyloid-β status. Results suggest a synergistic relationship between amyloid-β status and tau as predictors of change in memory and visuospatial cognition.

AB - This study investigates whether tau has (i) an independent effect from amyloid-β on changes in cognitive and functional performance and (ii) a synergistic relationship with amyloid-β in the exacerbation of decline in aging Down syndrome (DS). 105 participants with DS underwent baseline PET [18F]-AV1451 and PET [11C]PiB scans to quantify tau deposition in Braak regions II-VI and the Striatum and amyloid-β status respectively. Linear Mixed Effects models were implemented to assess how tau and amyloid-β deposition are related to change over three time points. Tau was a significant independent predictor of cognitive and functional change. The three-way interaction between time, [11C]PiB status and tau was significant in the models of episodic memory and visuospatial cognition. Baseline tau is a significant predictor of cognitive and functional decline, over and above the effect of amyloid-β status. Results suggest a synergistic relationship between amyloid-β status and tau as predictors of change in memory and visuospatial cognition.

KW - Alzheimer's disease

KW - Amyloid-β

KW - Down syndrome

KW - PET [C]PiB

KW - PET [F]-AV1451

KW - Tau

UR - http://www.scopus.com/inward/record.url?scp=85135781054&partnerID=8YFLogxK

U2 - 10.1016/j.neurobiolaging.2022.07.003

DO - 10.1016/j.neurobiolaging.2022.07.003

M3 - Article

C2 - 35964542

AN - SCOPUS:85135781054

SN - 0197-4580

VL - 119

SP - 36

EP - 45

JO - Neurobiology of Aging

JF - Neurobiology of Aging

ER -

Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome

Abstract

Keywords

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