@article{0f36be915c974d90aeefee2b977a6e6f,
title = "Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome",
abstract = "This study investigates whether tau has (i) an independent effect from amyloid-β on changes in cognitive and functional performance and (ii) a synergistic relationship with amyloid-β in the exacerbation of decline in aging Down syndrome (DS). 105 participants with DS underwent baseline PET [18F]-AV1451 and PET [11C]PiB scans to quantify tau deposition in Braak regions II-VI and the Striatum and amyloid-β status respectively. Linear Mixed Effects models were implemented to assess how tau and amyloid-β deposition are related to change over three time points. Tau was a significant independent predictor of cognitive and functional change. The three-way interaction between time, [11C]PiB status and tau was significant in the models of episodic memory and visuospatial cognition. Baseline tau is a significant predictor of cognitive and functional decline, over and above the effect of amyloid-β status. Results suggest a synergistic relationship between amyloid-β status and tau as predictors of change in memory and visuospatial cognition.",
keywords = "Alzheimer's disease, Amyloid-β, Down syndrome, PET [C]PiB, PET [F]-AV1451, Tau",
author = "Monika Grigorova and Elijah Mak and Brown, {Stephanie S.G.} and Jessica Beresford-Webb and Hong, {Young T.} and Fryer, {Tim D.} and Coles, {Jonathan P.} and Aigbirhio, {Franklin I.} and Dana Tudorascu and Annie Cohen and Christian, {Bradley T.} and Beau Ances and Handen, {Benjamin L.} and Laymon, {Charles M.} and Klunk, {William E.} and Clare, {Isabel C.H.} and Holland, {Anthony J.} and Zaman, {Shahid H.}",
note = "Funding Information: The data collection for this research was generously supported by a grant from the National Institute of Aging and the National Institute on Child Health and Human Development (U01AG051406). Dr Elijah Mak is supported by the Alzheimer's Society Junior Research Fellowship (RG9611; 443 JF-18- 017) as well as by Alzheimers Research UK (grant ARUK-PG2015-23). Dr JP Coles is supported by the NIHR Cambridge Biomedical Research Centre (BRC-1215-20014). Additional support came from the National Institute for Health Research, Cambridge Biomedical Research Centre, the National Institute for Health Research Collaborations in Leadership for Applied Health Research and Care for the East of England, the National Institute for Health Research Cambridge Dementia Biomedical Research Unit, the Down Syndrome Association. The views expressed are those of the authors and not necessarily those of the above funding bodies. Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
month = nov,
doi = "10.1016/j.neurobiolaging.2022.07.003",
language = "English",
volume = "119",
pages = "36--45",
journal = "Neurobiology of Aging",
issn = "0197-4580",
}