TY - JOUR
T1 - Amplitude of low-frequency fluctuations in bipolar disorder
T2 - A resting state fMRI study
AU - Xu, Ke
AU - Liu, Hu
AU - Li, Huanhuan
AU - Tang, Yanqing
AU - Womer, Fay
AU - Jiang, Xiaowei
AU - Chen, Kaiyuan
AU - Zhou, Yifang
AU - Jiang, Wenyan
AU - Luo, Xingguang
AU - Fan, Guoguang
AU - Wang, Fei
N1 - Funding Information:
This work was supported by the National Institute of Health (NIH) [K01MH086621 to F.W.]; the National Alliance for Research on Schizophrenia and Depression (Great Neck, NY) [F.W.]; the Klingenstein Foundation [F.W.]; the National Natural Science Foundation of China (81071099 to Y.T.) and the Liaoning Science and Technology Foundation (2008225010-14 to Y.T.).
PY - 2014/1
Y1 - 2014/1
N2 - Objectives The spontaneous low frequency fluctuations (LFF) of blood oxygenation level-dependent (BOLD) signal in resting state have been identified as a biological measure of baseline spontaneous activity in the brain. Increasingly, studies of spontaneous resting state functional connectivity have demonstrated neural network abnormalities in bipolar disorder (BD). This study used the amplitude of low frequency fluctuations (ALFF) to explore the regional functional changes in BD during resting state. Methods Twenty-nine BD participants and 29 matched healthy controls (HC) were recruited to undergo resting-state functional magnetic resonance imaging scan on a 3.0 T magnetic resonance imaging system. The ALFF of BOLD signal in gray matter for each participant was calculated, and then was compared between BD and HC using ALFF maps. Results Compared to the HC group, the BD group showed increased ALFF in ventral prefrontal cortex, dorsal lateral prefrontal cortex, frontal eye field, insula, and putamen with extension into the ventral striatum, as well as decreased ALFF in the lingual gyrus (p<0.05, corrected). Limitations Although we observed differences in ALFF between BD and HC, we cannot conclusively state that these differences are caused by the pathophysiology of BD since most of BD participants were being treated with medications at the time of scanning. Conclusions Our results revealed altered regional brain activity in BD during resting state. The affected regions have been associated with BD pathophysiology. This suggests that methods using ALFF method may potentially be useful in further studies of this disorder.
AB - Objectives The spontaneous low frequency fluctuations (LFF) of blood oxygenation level-dependent (BOLD) signal in resting state have been identified as a biological measure of baseline spontaneous activity in the brain. Increasingly, studies of spontaneous resting state functional connectivity have demonstrated neural network abnormalities in bipolar disorder (BD). This study used the amplitude of low frequency fluctuations (ALFF) to explore the regional functional changes in BD during resting state. Methods Twenty-nine BD participants and 29 matched healthy controls (HC) were recruited to undergo resting-state functional magnetic resonance imaging scan on a 3.0 T magnetic resonance imaging system. The ALFF of BOLD signal in gray matter for each participant was calculated, and then was compared between BD and HC using ALFF maps. Results Compared to the HC group, the BD group showed increased ALFF in ventral prefrontal cortex, dorsal lateral prefrontal cortex, frontal eye field, insula, and putamen with extension into the ventral striatum, as well as decreased ALFF in the lingual gyrus (p<0.05, corrected). Limitations Although we observed differences in ALFF between BD and HC, we cannot conclusively state that these differences are caused by the pathophysiology of BD since most of BD participants were being treated with medications at the time of scanning. Conclusions Our results revealed altered regional brain activity in BD during resting state. The affected regions have been associated with BD pathophysiology. This suggests that methods using ALFF method may potentially be useful in further studies of this disorder.
KW - Amplitude of low frequency fluctuation
KW - Bipolar disorder
KW - Resting state
KW - Spontaneous brain activity
UR - http://www.scopus.com/inward/record.url?scp=84889096907&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2013.09.017
DO - 10.1016/j.jad.2013.09.017
M3 - Article
C2 - 24120087
AN - SCOPUS:84889096907
SN - 0165-0327
VL - 152-154
SP - 237
EP - 242
JO - Journal of affective disorders
JF - Journal of affective disorders
IS - 1
ER -