Amphiphilic phthalocyanine-cyclodextrin conjugates for cancer photodynamic therapy

Leandro M.O. Lourenço; Patrícia M.R. Pereira; Elisabete Maciel; Mónica Válega; Fernando M.J. Domingues; Maria R.M. Domingues; Maria G.P.M.S. Neves; José A.S. Cavaleiro; Rosa Fernandes; João P.C. Tomé

doi:10.1039/c4cc02226b

Amphiphilic phthalocyanine-cyclodextrin conjugates for cancer photodynamic therapy

Leandro M.O. Lourenço
, Patrícia M.R. Pereira
, Elisabete Maciel
, Mónica Válega
, Fernando M.J. Domingues
, Maria R.M. Domingues
, Maria G.P.M.S. Neves
, José A.S. Cavaleiro
, Rosa Fernandes
, João P.C. Tomé

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

Three phthalocyanines (Pcs) conjugated with α-, β- and γ-cyclodextrins (CDs) were prepared and their application as photosensitizer (PS) agents was assessed by photophysical, photochemical and in vitro photobiological studies. The photoactivity of Pc-α-CD and Pc-γ-CD ensures their potential as PDT drugs against UM-UC-3 human bladder cancer cells.

Original language	English
Pages (from-to)	8363-8366
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	61
DOIs	https://doi.org/10.1039/c4cc02226b
State	Published - Jul 3 2014

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title = "Amphiphilic phthalocyanine-cyclodextrin conjugates for cancer photodynamic therapy",

abstract = "Three phthalocyanines (Pcs) conjugated with α-, β- and γ-cyclodextrins (CDs) were prepared and their application as photosensitizer (PS) agents was assessed by photophysical, photochemical and in vitro photobiological studies. The photoactivity of Pc-α-CD and Pc-γ-CD ensures their potential as PDT drugs against UM-UC-3 human bladder cancer cells.",

author = "Louren{\c c}o, \{Leandro M.O.\} and Pereira, \{Patr{\'i}cia M.R.\} and Elisabete Maciel and M{\'o}nica V{\'a}lega and Domingues, \{Fernando M.J.\} and Domingues, \{Maria R.M.\} and Neves, \{Maria G.P.M.S.\} and Cavaleiro, \{Jos{\'e} A.S.\} and Rosa Fernandes and Tom{\'e}, \{Jo{\~a}o P.C.\}",

year = "2014",

month = jul,

day = "3",

doi = "10.1039/c4cc02226b",

language = "English",

volume = "50",

pages = "8363--8366",

journal = "Chemical Communications",

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number = "61",

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TY - JOUR

T1 - Amphiphilic phthalocyanine-cyclodextrin conjugates for cancer photodynamic therapy

AU - Lourenço, Leandro M.O.

AU - Pereira, Patrícia M.R.

AU - Maciel, Elisabete

AU - Válega, Mónica

AU - Domingues, Fernando M.J.

AU - Domingues, Maria R.M.

AU - Neves, Maria G.P.M.S.

AU - Cavaleiro, José A.S.

AU - Fernandes, Rosa

AU - Tomé, João P.C.

PY - 2014/7/3

Y1 - 2014/7/3

N2 - Three phthalocyanines (Pcs) conjugated with α-, β- and γ-cyclodextrins (CDs) were prepared and their application as photosensitizer (PS) agents was assessed by photophysical, photochemical and in vitro photobiological studies. The photoactivity of Pc-α-CD and Pc-γ-CD ensures their potential as PDT drugs against UM-UC-3 human bladder cancer cells.

AB - Three phthalocyanines (Pcs) conjugated with α-, β- and γ-cyclodextrins (CDs) were prepared and their application as photosensitizer (PS) agents was assessed by photophysical, photochemical and in vitro photobiological studies. The photoactivity of Pc-α-CD and Pc-γ-CD ensures their potential as PDT drugs against UM-UC-3 human bladder cancer cells.

UR - https://www.scopus.com/pages/publications/84903973409

U2 - 10.1039/c4cc02226b

DO - 10.1039/c4cc02226b

M3 - Article

C2 - 24943806

AN - SCOPUS:84903973409

SN - 1359-7345

VL - 50

SP - 8363

EP - 8366

JO - Chemical Communications

JF - Chemical Communications

IS - 61

ER -

Amphiphilic phthalocyanine-cyclodextrin conjugates for cancer photodynamic therapy

Abstract

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