Amphiphilic phthalocyanine-cyclodextrin conjugates for cancer photodynamic therapy

Leandro M.O. Lourenço, Patrícia M.R. Pereira, Elisabete Maciel, Mónica Válega, Fernando M.J. Domingues, Maria R.M. Domingues, Maria G.P.M.S. Neves, José A.S. Cavaleiro, Rosa Fernandes, João P.C. Tomé

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94 Scopus citations

Abstract

Three phthalocyanines (Pcs) conjugated with α-, β- and γ-cyclodextrins (CDs) were prepared and their application as photosensitizer (PS) agents was assessed by photophysical, photochemical and in vitro photobiological studies. The photoactivity of Pc-α-CD and Pc-γ-CD ensures their potential as PDT drugs against UM-UC-3 human bladder cancer cells.

Original languageEnglish
Pages (from-to)8363-8366
Number of pages4
JournalChemical Communications
Volume50
Issue number61
DOIs
StatePublished - Jul 3 2014

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