Aminopyridines mimic mutant Drosophila developmental defects

Lawrence Salkoff, Leonard Kelly

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

1. The potassium blocking agents 2- and 3-aminopyridine cause developmental defects in Drosophila melanogaster when these agents are fed to third-instar larvae. The developmental defects thus produced are similar in appearance to the developmental phenotypes produced by mutations at the shibire and Notch loci. 2. Aminopyridine drugs enhance neuromuscular transmission at the Drosophila larval neuromuscular junction. The effect can be attributed to their potassium-blocking action in the presynaptic nerve terminal.

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume65
Issue number1
DOIs
StatePublished - 1980

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