Aminopyridines mimic mutant Drosophila developmental defects

Lawrence Salkoff; Leonard Kelly

doi:10.1016/0306-4492(80)90046-5

Aminopyridines mimic mutant Drosophila developmental defects

Lawrence Salkoff, Leonard Kelly

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Abstract

1. The potassium blocking agents 2- and 3-aminopyridine cause developmental defects in Drosophila melanogaster when these agents are fed to third-instar larvae. The developmental defects thus produced are similar in appearance to the developmental phenotypes produced by mutations at the shibire and Notch loci. 2. Aminopyridine drugs enhance neuromuscular transmission at the Drosophila larval neuromuscular junction. The effect can be attributed to their potassium-blocking action in the presynaptic nerve terminal.

Original language	English
Pages (from-to)	59-63
Number of pages	5
Journal	Comparative Biochemistry and Physiology. Part C, Comparative
Volume	65
Issue number	1
DOIs	https://doi.org/10.1016/0306-4492(80)90046-5
State	Published - 1980

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title = "Aminopyridines mimic mutant Drosophila developmental defects",

abstract = "1. The potassium blocking agents 2- and 3-aminopyridine cause developmental defects in Drosophila melanogaster when these agents are fed to third-instar larvae. The developmental defects thus produced are similar in appearance to the developmental phenotypes produced by mutations at the shibire and Notch loci. 2. Aminopyridine drugs enhance neuromuscular transmission at the Drosophila larval neuromuscular junction. The effect can be attributed to their potassium-blocking action in the presynaptic nerve terminal.",

author = "Lawrence Salkoff and Leonard Kelly",

year = "1980",

doi = "10.1016/0306-4492(80)90046-5",

language = "English",

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pages = "59--63",

journal = "Comparative Biochemistry and Physiology. Part C, Comparative",

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number = "1",

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T1 - Aminopyridines mimic mutant Drosophila developmental defects

AU - Salkoff, Lawrence

AU - Kelly, Leonard

PY - 1980

Y1 - 1980

N2 - 1. The potassium blocking agents 2- and 3-aminopyridine cause developmental defects in Drosophila melanogaster when these agents are fed to third-instar larvae. The developmental defects thus produced are similar in appearance to the developmental phenotypes produced by mutations at the shibire and Notch loci. 2. Aminopyridine drugs enhance neuromuscular transmission at the Drosophila larval neuromuscular junction. The effect can be attributed to their potassium-blocking action in the presynaptic nerve terminal.

AB - 1. The potassium blocking agents 2- and 3-aminopyridine cause developmental defects in Drosophila melanogaster when these agents are fed to third-instar larvae. The developmental defects thus produced are similar in appearance to the developmental phenotypes produced by mutations at the shibire and Notch loci. 2. Aminopyridine drugs enhance neuromuscular transmission at the Drosophila larval neuromuscular junction. The effect can be attributed to their potassium-blocking action in the presynaptic nerve terminal.

UR - http://www.scopus.com/inward/record.url?scp=0018830121&partnerID=8YFLogxK

U2 - 10.1016/0306-4492(80)90046-5

DO - 10.1016/0306-4492(80)90046-5

M3 - Article

AN - SCOPUS:0018830121

SN - 0306-4492

VL - 65

SP - 59

EP - 63

JO - Comparative Biochemistry and Physiology. Part C, Comparative

JF - Comparative Biochemistry and Physiology. Part C, Comparative

IS - 1

ER -

Aminopyridines mimic mutant Drosophila developmental defects

Abstract

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