American Head and Neck Society Endocrine Surgery Section and International Thyroid Oncology Group consensus statement on mutational testing in thyroid cancer: Defining advanced thyroid cancer and its targeted treatment

David C. Shonka, Alan Ho, Ashish V. Chintakuntlawar, Jessica L. Geiger, Jong C. Park, Nagashree Seetharamu, Sina Jasim, Amr H. Abdelhamid Ahmed, Keith C. Bible, Marcia S. Brose, Maria E. Cabanillas, Kirsten Dabekaussen, Louise Davies, Dora Dias-Santagata, James A. Fagin, William C. Faquin, Ronald A. Ghossein, Raj K. Gopal, Akira Miyauchi, Yuri E. NikiforovMatthew D. Ringel, Bruce Robinson, Mabel M. Ryder, Eric J. Sherman, Peter M. Sadow, Jennifer J. Shin, Brendan C. Stack, R. Michael Tuttle, Lori J. Wirth, Mark E. Zafereo, Gregory W. Randolph

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: The development of systemic treatment options leveraging the molecular landscape of advanced thyroid cancer is a burgeoning field. This is a multidisciplinary evidence-based statement on the definition of advanced thyroid cancer and its targeted systemic treatment. Methods: An expert panel was assembled, a literature review was conducted, and best practice statements were developed. The modified Delphi method was applied to assess the degree of consensus for the statements developed by the author panel. Results: A review of the current understanding of thyroid oncogenesis at a molecular level is presented and characteristics of advanced thyroid cancer are defined. Twenty statements in topics including the multidisciplinary management, molecular evaluation, and targeted systemic treatment of advanced thyroid cancer are provided. Conclusions: With the growth in targeted treatment options for thyroid cancer, a consensus definition of advanced disease and statements regarding the utility of molecular testing and available targeted systemic therapy is warranted.

Original languageEnglish
Pages (from-to)1277-1300
Number of pages24
JournalHead and Neck
Volume44
Issue number6
DOIs
StatePublished - Jun 2022

Keywords

  • advanced thyroid cancer
  • consensus statement
  • molecular testing
  • systemic therapy
  • targeted treatment

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