Abstract
Normal aging of the brain involves an interplay of heterogeneous cellular and molecular events, which when aggravated tend to switch normal aging of the brain to the pathological aging of the brain, leading to the development of neurodegenerative diseases and dementia. Currently there are ~35 million people worldwide living with dementia, and this number will triple by 2050 if effective preventative measures are not discovered. Currently used single-ingredient monotherapeutic drug(s) for treating neurodegeneration fail to address the heterogeneity of the aging brain. In that regard, pleiotropic nutraceuticals aimed at simultaneously treating multiple therapeutic targets with the least adverse effects possible may be more effective in promoting healthy aging of the brain than pharmaceutical monotherapy. Nutraceuticals contain a balanced combination of beneficial macro- and micronutrients that are difficult to synthesize in the laboratory. This chapter reviews the neuroprotective multiplicity of commonly consumed nutraceuticals in preventing pathological aging of the brain while simultaneously promoting healthy aging of the brain.
| Original language | English |
|---|---|
| Title of host publication | Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease |
| Subtitle of host publication | Prevention and Therapy |
| Publisher | Elsevier Inc. |
| Pages | 245-260 |
| Number of pages | 16 |
| ISBN (Electronic) | 9780124115293 |
| ISBN (Print) | 9780124114623 |
| DOIs | |
| State | Published - 2015 |
Keywords
- Anti-inflammatory effects
- Antioxidant effects
- Cholinergic enhancement
- Cognition
- Dementia
- Herbal polypharmacy
- HMG-CoA reductase inhibitors
- Neurological diseases
- Protein misfolding
- Synaptotrophic effects