Ambient air pollution and preterm birth: A prospective birth cohort study in Wuhan, China

Importance: Although studies in western countries suggest that ambient air pollution is positively associated with adverse pregnancy outcomes, the upper levels of pollutant exposures have been relatively low, thus eroding confidence in the conclusions. Meanwhile, in Asia, where upper levels of exposure have been greater, there have been limited studies of the association between air pollution and adverse pregnancy outcomes. Objective: The primary objective was to evaluate whether high levels of pollution, including particulate matter pollution with a mass median aerodynamic diameter of less than 2.5 μm (PM_2.5) and 10 μm (PM₁₀), sulfur dioxide (SO₂), nitrogen dioxide (NO₂), ozone (O₃), and carbon monoxide (CO) are related to increased occurrence of preterm birth (PTB). Methods: We conducted a population-based study in Wuhan, China in a cohort of 95,911 live births during a two-year period from 2011 to 2013. The exposure was estimated based on daily mean concentrations of pollutants estimated using the pollutants' measurements from the nine closest monitors. Logistic regressions were performed to determine the relationships between exposure to each of the pollutants during different pregnancy periods and PTB while controlling for key covariates. Results: We found 3% (OR = 1.03; 95% CI: 1.02, 1.05), 2% (OR = 1.02; 95% CI: 1.02, 1.03), 15% (OR = 1.15; 95% CI: 1.11, 1.19), and 5% (OR = 1.05; 95% CI: 1.02, 1.07) increases in risk of PTB with each 5-μg/m³ increase in PM_2.5 and PM₁₀ concentrations, 100-μg/m³ increase in CO concentrations, and 10-μg/m³ increase in O₃ concentrations, respectively. There was negligible evidence for associations for SO₂ and NO₂. The effects from two-pollutant models were similar to the estimated effects from single pollutant models. No critical exposure windows were identified consistently: the strongest effect for PTB was found in the second trimester for PM_2.5, PM₁₀, and CO, but for SO₂ it was in the first trimester, second month, and third month. For NO₂ it was in the first trimester and second month, and for O₃, the third trimester. Conclusion: Findings reveal an association between air pollutants and PTB. However, more toxicological studies and prospective cohort studies with improved exposure assessments are needed to establish causality related to specific pollutants.