Alzheimer's Aβ vaccination of rhesus monkeys (Macaca mulatta)

Sam Gandy, Ron B. DeMattos, Cynthia A. Lemere, Frank L. Heppner, Jodi Leverone, Adriano Aguzzi, William B. Ershler, Jinlu Dai, Paul Fraser, Peter St George Hyslop, David M. Holtzman, Lary C. Walker, Evan T. Keller

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Recent preliminary data suggest that vaccination with Alzheimer's Aβ might reduce senile plaque load and stabilize cognitive decline in human Alzheimer's disease. To examine the mechanisms and consequences of anti-Aβ-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated Aβ 1-42. Immunized monkeys developed anti-Aβ titers exceeding 1:1000, and their plasma Aβ levels were 5-10-fold higher than the plasma Aβ levels observed in monkeys vaccinated with aggregated amylin. These data support the use of non-human primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer's Aβ.

Original languageEnglish
Pages (from-to)149-151
Number of pages3
JournalMechanisms of Ageing and Development
Volume125
Issue number2
DOIs
StatePublished - Feb 2004

Keywords

  • Alzheimer's vaccination
  • Alzheimers
  • Immunization
  • Rhesus monkey

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