TY - JOUR
T1 - Alzheimer Disease Biomarkers and Driving in Clinically Normal Older Adults
AU - Allison, Samantha
AU - Babulal, Ganesh M.
AU - Stout, Sarah H.
AU - Barco, Peggy P.
AU - Carr, David B.
AU - Fagan, Anne M.
AU - Morris, John C.
AU - Roe, Catherine M.
AU - Head, Denise
N1 - Publisher Copyright:
© 2017 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Purpose: Older adults experience impaired driving performance, and modify their driving habits, including limiting amount and spatial extent of travel. Alzheimer disease (AD)-related pathology, as well as spatial navigation difficulties, may influence driving performance and driving behaviors in clinically normal older adults. We examined whether AD biomarkers [cerebrospinal fluid (CSF) concentrations of Aβ 42, tau, and ptau 181 ] were associated with lower self-reported spatial navigation abilities, and whether navigation abilities mediated the relationship of AD biomarkers with driving performance and extent. Methods: Clinically normal older adults (n=112; aged 65+) completed an on-road driving test, the Santa Barbara Sense of Direction scale (self-report measure of spatial navigation ability), and the Driving Habits Questionnaire for an estimate of driving extent (composite of driving exposure and driving space). All participants had a lumbar puncture to obtain CSF. Results: CSF Aβ 42, but not tau or ptau 181, was associated with self-reported navigation ability. Lower self-reported navigation was associated with reduced driving extent, but not driving errors. Self-reported navigation mediated the relationship between CSF Aβ 42 and driving extent. Conclusions: Findings suggest that cerebral amyloid deposition is associated with lower perceived ability to navigate the environment, which may lead older adults with AD pathology to limit their driving extent.
AB - Purpose: Older adults experience impaired driving performance, and modify their driving habits, including limiting amount and spatial extent of travel. Alzheimer disease (AD)-related pathology, as well as spatial navigation difficulties, may influence driving performance and driving behaviors in clinically normal older adults. We examined whether AD biomarkers [cerebrospinal fluid (CSF) concentrations of Aβ 42, tau, and ptau 181 ] were associated with lower self-reported spatial navigation abilities, and whether navigation abilities mediated the relationship of AD biomarkers with driving performance and extent. Methods: Clinically normal older adults (n=112; aged 65+) completed an on-road driving test, the Santa Barbara Sense of Direction scale (self-report measure of spatial navigation ability), and the Driving Habits Questionnaire for an estimate of driving extent (composite of driving exposure and driving space). All participants had a lumbar puncture to obtain CSF. Results: CSF Aβ 42, but not tau or ptau 181, was associated with self-reported navigation ability. Lower self-reported navigation was associated with reduced driving extent, but not driving errors. Self-reported navigation mediated the relationship between CSF Aβ 42 and driving extent. Conclusions: Findings suggest that cerebral amyloid deposition is associated with lower perceived ability to navigate the environment, which may lead older adults with AD pathology to limit their driving extent.
KW - amyloid deposition
KW - driving space
KW - on-road driving test
KW - preclinical Alzheimer disease
UR - http://www.scopus.com/inward/record.url?scp=85048034937&partnerID=8YFLogxK
U2 - 10.1097/WAD.0000000000000257
DO - 10.1097/WAD.0000000000000257
M3 - Article
C2 - 29578861
AN - SCOPUS:85048034937
SN - 0893-0341
VL - 32
SP - 101
EP - 106
JO - Alzheimer disease and associated disorders
JF - Alzheimer disease and associated disorders
IS - 2
ER -