@article{98029cd7379247699cb7a3f70d4ea124,
title = "Alzheimer Disease: An Update on Pathobiology and Treatment Strategies",
abstract = "Long & Holtzman provide a comprehensive overview of the molecules, cells, and mechanisms of Alzheimer disease pathobiology and therapeutic strategies, critically discussing failed strategies and offering a path forward.",
author = "Long, {Justin M.} and Holtzman, {David M.}",
note = "Funding Information: This work was supported by a grant from the Alzheimer's Association to J.M.L. (AACSF-18-564776) and NIH grants (NS090934, AG047644, and NS074969) as well as grants from the Tau consortium, the JPB Foundation, and Cure Alzheimer's Fund to D.M.H. Conceptualization, J.M.L. and D.M.H.; Writing – Original Draft, J.M.L.; Writing – Revising & Editing, J.M.L. and D.M.H.; Funding Acquisition, J.M.L. and D.M.H.; Supervision, D.M.H. J.M.L. reports serving as sub-investigator on the Lilly TRAILBLAZER trial but receives no financial compensation. D.M.H. reports being a co-founder of C2N Diagnostics; being on the scientific advisory board of C2N Diagnostics, Denali, and Genentech; and being a consultant for AbbVie and Idorsia. D.M.H is an inventor on a submitted patent #PCT/US2013/049333 “Antibodies to tau” that is licensed by Washington University to C2N Diagnostics. This patent was subsequently licensed to AbbVie. D.M.H. is an inventor on patent number 8,591,894 “Humanized antibodies that sequester amyloid beta” that was licensed by Washington University to Eli Lilly. D.M.H. is an inventor on patent number 8,232,107 “Methods for measuring the metabolism of neurally derived biomolecules in vivo” that was licensed by Washington University to C2N Diagnostics. Funding Information: This work was supported by a grant from the Alzheimer's Association to J.M.L. ( AACSF-18-564776 ) and NIH grants ( NS090934 , AG047644 , and NS074969 ) as well as grants from the Tau consortium , the JPB Foundation , and Cure Alzheimer's Fund to D.M.H. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = oct,
day = "3",
doi = "10.1016/j.cell.2019.09.001",
language = "English",
volume = "179",
pages = "312--339",
journal = "Cell",
issn = "0092-8674",
number = "2",
}