Recent preliminary data suggest that vaccination with Alzheimer Aβ might reduce senile plaque load and stabilize cognitive decline in human Alzheimer disease. To examine the mechanisms and consequences of anti-Aβ-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated Aβ1-42. Immunized monkeys developed anti-Aβ titers exceeding 1:1000, and their plasma Aβ levels were 5-to 10-fold higher than the plasma Aβ levels observed in monkeys vaccinated with aggregated amylin. These data support the use of nonhuman primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer Aβ.
- Immunoglobulin G