Alternative diastolic function models of ventricular longitudinal filling velocity are mathematically identical

Druv Bhagavan, William M. Padovano, Sándor J. Kovács

Research output: Contribution to journalArticlepeer-review

Abstract

The spatiotemporal features of normal in vivo cardiac motion are well established. Longitudinal velocity has become a focus of diastolic function (DF) characterization, particularly the tissue Doppler e'-wave, manifesting in early diastole when the left ventricle (LV) is a mechanical suction pump (dP/dV < 0). To characterize DF and elucidate mechanistic features, several models have been proposed and have been previously compared algebraically, numerically, and in their ability to fit physiological velocity data. We analyze two previously noncompared models of early rapid-filling lengthening velocity (Doppler e'-wave): parametrized diastolic filling (PDF) and force balance model (FBM). Our initial numerical experiments sampled FBM-generated e'(t) contours as input to determine PDF model predicted fit. The resulting exact numerical agreement [standard error of regression (SER) = 9.06 × 10-16] was not anticipated. Therefore, we analyzed all published FBM-generated e'(t) contours and observed identical agreement. We re-expressed FBM's algebraic expressions for e'(t) and observed for the first time that model-based predictions for lengthening velocity by the FBM and the PDF model are mathematically identical: e'(t) = γe-αtsinh(βt), thereby providing exact algebraic relations between the three PDF parameters and the six FBM parameters. Previous pioneering experiments have independently established the unique determinants of e'(t) to be LV relaxation, restoring forces (stiffness), and load. In light of the exact intermodel agreement, we conclude that the three PDF parameters, relaxation, stiffness (restoring forces), and load, are unique determinants of DF and e'(t). Thus, we show that only the PDF formalism can compute the three unique, independent, physiological determinants of long-axis LV myocardial velocity from e'(t).NEW & NOTEWORTHY We show that two separate, independently derived physiological (kinematic) models predict mathematically identical expressions for LV-lengthening velocity (Doppler e'-wave), indicating that damped harmonic oscillatory motion is a physiologically accurate model of diastolic function. Although both models predict the same "overdamped" velocity contour, only one model solves the "inverse problem" and generates unique, lumped parameters of relaxation, stiffness (restoring force), and load from the e'-wave.

Original languageEnglish
Pages (from-to)H1059-H1067
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume318
Issue number5
DOIs
StatePublished - May 1 2020

Keywords

  • diastolic function
  • echocardiography
  • left ventricular function
  • lengthening velocity
  • mathematical modeling

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