TY - GEN
T1 - ALTERED SWELLING-INDUCED STRAIN FIELDS IN ARTICULAR CARTILAGE FOLLOWING PERIODS OF IMMOBILIZATION
AU - Narmoneva, D. A.
AU - Wang, J. Y.
AU - Patel, S. S.
AU - Howell, D. S.
AU - Setton, L. A.
N1 - Funding Information:
This work was supported by grants from NSF, The Whitaker Foundation and funds from VA Rehabilitation Merit Award.
Publisher Copyright:
© 1997 American Society of Mechanical Engineers (ASME). All rights reserved.
PY - 1997
Y1 - 1997
N2 - Swelling effects in cartilage arise from a high density of negatively-charged proteoglycans which generate a large swelling pressure. Swelling effects in cartilage are regulated by a balance between this swelling pressure and elastic forces generated within the cartilage solid matrix (1,2). Increased swelling is a characteristic of osteoarthritic cartilage and reflects a pathological alteration in the balance between swelling pressure and elastic restraining forces (3). Recently, we have developed a new technique to measure the nonuniform swelling-induced strain fields in samples of articular cartilage in situ, i.e., while attached to the subchondral bone (4). We observed variations in swelling behavior of cartilage with depth from the articular surface, reflecting the nonhomogeneous composition and structure of the material. In this study, we apply our newly-developed experimental technique to measure the swelling-induced strain fields in cartilage following removal of weight-bearing forces with cast immobilization. Periods of joint immobilization have been shown to produce compositional changes characteristic of osteoarthritis including a decreased proteoglycan content and changes in proteoglycan conformation (5, 6). We hypothesize that the changes associated with joint immobilization will alter the swelling behavior of articular cartilage, which will be detected as a change in swelling-induced strain fields in cartilage in situ.
AB - Swelling effects in cartilage arise from a high density of negatively-charged proteoglycans which generate a large swelling pressure. Swelling effects in cartilage are regulated by a balance between this swelling pressure and elastic forces generated within the cartilage solid matrix (1,2). Increased swelling is a characteristic of osteoarthritic cartilage and reflects a pathological alteration in the balance between swelling pressure and elastic restraining forces (3). Recently, we have developed a new technique to measure the nonuniform swelling-induced strain fields in samples of articular cartilage in situ, i.e., while attached to the subchondral bone (4). We observed variations in swelling behavior of cartilage with depth from the articular surface, reflecting the nonhomogeneous composition and structure of the material. In this study, we apply our newly-developed experimental technique to measure the swelling-induced strain fields in cartilage following removal of weight-bearing forces with cast immobilization. Periods of joint immobilization have been shown to produce compositional changes characteristic of osteoarthritis including a decreased proteoglycan content and changes in proteoglycan conformation (5, 6). We hypothesize that the changes associated with joint immobilization will alter the swelling behavior of articular cartilage, which will be detected as a change in swelling-induced strain fields in cartilage in situ.
UR - http://www.scopus.com/inward/record.url?scp=85126971046&partnerID=8YFLogxK
U2 - 10.1115/IMECE1997-0260
DO - 10.1115/IMECE1997-0260
M3 - Conference contribution
AN - SCOPUS:85126971046
T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
SP - 125
EP - 126
BT - Advances in Bioengineering
PB - American Society of Mechanical Engineers (ASME)
T2 - ASME 1997 International Mechanical Engineering Congress and Exposition, IMECE 1997 - Advances in Bioengineering
Y2 - 16 November 1997 through 21 November 1997
ER -