TY - JOUR
T1 - Altered slow wave activity in major depressive disorder with hypersomnia
T2 - A high density EEG pilot study
AU - Plante, David T.
AU - Landsness, Eric C.
AU - Peterson, Michael J.
AU - Goldstein, Michael R.
AU - Wanger, Tim
AU - Guokas, Jeff J.
AU - Tononi, Giulio
AU - Benca, Ruth M.
N1 - Funding Information:
This research was funded by the National Institute of Mental Health (5P20MH077967 to GT and RMB, and F30MH082601 to EL) and the National Alliance for Research on Schizophrenia and Depression Young Investigator Award to MJP. We thank Drs. Brady Riedner and Vlad Vyazovskiy for their technical assistance, and Miss Seugnet Miller who assisted with preparation of the manuscript.
PY - 2012/3/31
Y1 - 2012/3/31
N2 - Hypersomnolence in major depressive disorder (MDD) plays an important role in the natural history of the disorder, but the basis of hypersomnia in MDD is poorly understood. Slow wave activity (SWA) has been associated with sleep homeostasis, as well as sleep restoration and maintenance, and may be altered in MDD. Therefore, we conducted a post-hoc study that utilized high density electroencephalography (hdEEG) to test the hypothesis that MDD subjects with hypersomnia (HYS+) would have decreased SWA relative to age- and sex-matched MDD subjects without hypersomnia (HYS-) and healthy controls (n= 7 for each group). After correction for multiple comparisons using statistical non-parametric mapping, HYS+ subjects demonstrated significantly reduced parieto-occipital all-night SWA relative to HYS- subjects. Our results suggest hypersomnolence may be associated with topographic reductions in SWA in MDD. Further research using an adequately powered prospective design is indicated to confirm these findings.
AB - Hypersomnolence in major depressive disorder (MDD) plays an important role in the natural history of the disorder, but the basis of hypersomnia in MDD is poorly understood. Slow wave activity (SWA) has been associated with sleep homeostasis, as well as sleep restoration and maintenance, and may be altered in MDD. Therefore, we conducted a post-hoc study that utilized high density electroencephalography (hdEEG) to test the hypothesis that MDD subjects with hypersomnia (HYS+) would have decreased SWA relative to age- and sex-matched MDD subjects without hypersomnia (HYS-) and healthy controls (n= 7 for each group). After correction for multiple comparisons using statistical non-parametric mapping, HYS+ subjects demonstrated significantly reduced parieto-occipital all-night SWA relative to HYS- subjects. Our results suggest hypersomnolence may be associated with topographic reductions in SWA in MDD. Further research using an adequately powered prospective design is indicated to confirm these findings.
KW - Depression
KW - Sleep
KW - Spectral analysis
UR - http://www.scopus.com/inward/record.url?scp=84861456115&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2012.03.001
DO - 10.1016/j.pscychresns.2012.03.001
M3 - Article
C2 - 22512951
AN - SCOPUS:84861456115
SN - 0925-4927
VL - 201
SP - 240
EP - 244
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 3
ER -