Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease

E. Masliah, M. Mallory, M. Alford, R. DeTeresa, L. A. Hansen, D. W. McKeel, J. C. Morris

Research output: Contribution to journalArticlepeer-review

598 Scopus citations

Abstract

The expression levels of three synaptic proteins (synaptophysin, synaptotagmin, and growth-associated protein 43 [GAP43]) in AD cases clinically classified by Clinical Dementia Rating (CDR) score were analyzed. Compared with control subjects (CDR = 0), mild (early) AD (CDR = 0.5 to 1) cases had a 25% loss of synaptophysin immunoreactivity. Levels of synaptotagmin and GAP43 were unchanged in mild AD, but cases with CDR of >1 had a progressive decrement in these synaptic proteins. Thus, synaptic injury in frontal cortex is an early event in AD.

Original languageEnglish
Pages (from-to)127-129
Number of pages3
JournalNeurology
Volume56
Issue number1
DOIs
StatePublished - Jan 9 2001

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