Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease

E. Masliah; M. Mallory; M. Alford; R. DeTeresa; L. A. Hansen; D. W. McKeel; J. C. Morris

doi:10.1212/WNL.56.1.127

Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease

E. Masliah, M. Mallory, M. Alford, R. DeTeresa, L. A. Hansen, D. W. McKeel, J. C. Morris

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Abstract

The expression levels of three synaptic proteins (synaptophysin, synaptotagmin, and growth-associated protein 43 [GAP43]) in AD cases clinically classified by Clinical Dementia Rating (CDR) score were analyzed. Compared with control subjects (CDR = 0), mild (early) AD (CDR = 0.5 to 1) cases had a 25% loss of synaptophysin immunoreactivity. Levels of synaptotagmin and GAP43 were unchanged in mild AD, but cases with CDR of >1 had a progressive decrement in these synaptic proteins. Thus, synaptic injury in frontal cortex is an early event in AD.

Original language	English
Pages (from-to)	127-129
Number of pages	3
Journal	Neurology
Volume	56
Issue number	1
DOIs	https://doi.org/10.1212/WNL.56.1.127
State	Published - Jan 9 2001

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abstract = "The expression levels of three synaptic proteins (synaptophysin, synaptotagmin, and growth-associated protein 43 [GAP43]) in AD cases clinically classified by Clinical Dementia Rating (CDR) score were analyzed. Compared with control subjects (CDR = 0), mild (early) AD (CDR = 0.5 to 1) cases had a 25% loss of synaptophysin immunoreactivity. Levels of synaptotagmin and GAP43 were unchanged in mild AD, but cases with CDR of >1 had a progressive decrement in these synaptic proteins. Thus, synaptic injury in frontal cortex is an early event in AD.",

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AU - Masliah, E.

AU - Mallory, M.

AU - Alford, M.

AU - DeTeresa, R.

AU - Hansen, L. A.

AU - McKeel, D. W.

AU - Morris, J. C.

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N2 - The expression levels of three synaptic proteins (synaptophysin, synaptotagmin, and growth-associated protein 43 [GAP43]) in AD cases clinically classified by Clinical Dementia Rating (CDR) score were analyzed. Compared with control subjects (CDR = 0), mild (early) AD (CDR = 0.5 to 1) cases had a 25% loss of synaptophysin immunoreactivity. Levels of synaptotagmin and GAP43 were unchanged in mild AD, but cases with CDR of >1 had a progressive decrement in these synaptic proteins. Thus, synaptic injury in frontal cortex is an early event in AD.

AB - The expression levels of three synaptic proteins (synaptophysin, synaptotagmin, and growth-associated protein 43 [GAP43]) in AD cases clinically classified by Clinical Dementia Rating (CDR) score were analyzed. Compared with control subjects (CDR = 0), mild (early) AD (CDR = 0.5 to 1) cases had a 25% loss of synaptophysin immunoreactivity. Levels of synaptotagmin and GAP43 were unchanged in mild AD, but cases with CDR of >1 had a progressive decrement in these synaptic proteins. Thus, synaptic injury in frontal cortex is an early event in AD.

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JO - Neurology

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Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease

Abstract

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