Alterations in cerebral oxygen metabolism after traumatic brain injury in children

Dustin K. Ragan, Robert McKinstry, Tammie Benzinger, Jeffrey R. Leonard, Jose A. Pineda

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Traumatic brain injury (TBI) is the most common cause of acquired disability in children. Metabolic defects, and in particular mitochondrial dysfunction, are important contributors to brain injury after TBI. Studies of metabolic dysfunction are limited, but magnetic resonance methods suitable for use in children are overcoming this limitation. We performed noninvasive measurements of cerebral blood flow and oxygen metabolic index (OMI) to assess metabolic dysfunction in children with severe TBI. Cerebral blood flow is variable after TBI but hypoperfusion and low OMI are predominant, supporting metabolic dysfunction. This finding is consistent with preclinical and adult clinical studies of brain metabolism and mitochondrial dysfunction after TBI.

Original languageEnglish
Pages (from-to)48-52
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Volume33
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • brain imaging
  • brain trauma
  • cerebral blood flow

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