Alpha-substituted γ-butyrolactones: New class of anticonvulsant drugs

William E. Klunk, Ann C. McKeon, Douglas F. Covey, James A. Ferrendelli

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Alkyl-Substituted γ-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, α, α-dimethyl-, and α-ethyl-α-methyl-α-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted γ-butyrolactones represent a new class of anticonvulsant drugs with experimental and clinical potential.

Original languageEnglish
Pages (from-to)1040-1042
Number of pages3
Issue number4564
StatePublished - 1982


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