Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog

Keyphrases

• Trypanosomatids 100%
• Allosteric Activation 100%
• Deoxyhypusine Hydroxylase 100%
• Enzyme Activity 66%
• Spermidine 66%
• Gene Expression 33%
• Co-expression 33%
• Conditional Knockout 33%
• Drug Target 33%
• Eukaryotic Cells 33%
• Transcriptional Regulation 33%
• Fold Increase 33%
• Lysine Residue 33%
• Infectivity 33%
• Enzyme-mediated 33%
• Biosynthetic Enzymes 33%
• Heterodimer Formation 33%
• T. Brucei 33%
• Trypanosoma Brucei 33%
• In Vitro Growth 33%
• African Trypanosomes 33%
• Functional Complexity 33%
• Heterotetramer 33%
• S-adenosylmethionine Decarboxylase 33%
• Paralogous 33%
• Translation Initiation Factor 33%
• Human African Trypanosomiasis 33%
• Eflornithine 33%
• Eukaryotic Translation Initiation Factor 5A (eIF5A) 33%
• Polyamine Spermidine 33%
• Polyamine Biosynthesis 33%
• Hypusine Modification 33%
• Expression in Escherichia Coli 33%
• Recurrent Evolution 33%
• Difluoromethylornithine 33%

Biochemistry, Genetics and Molecular Biology

• Enzyme 100%
• Synthase 100%
• Trypanosomatidae 100%
• Paralogy 100%
• Anabolism 66%
• Enzyme Activity 66%
• Gene Expression 33%
• Escherichia coli 33%
• Trypanosoma Brucei 33%
• Heterotetramer 33%
• Trypanosoma 33%
• Adenosylmethionine Decarboxylase 33%
• Lysine 33%