TY - JOUR
T1 - Alloantigen recognition by two human natural killer cell clones is associated with HLA-C or a closely linked gene
AU - Colonna, M.
AU - Spies, T.
AU - Strominger, J. L.
AU - Ciccone, E.
AU - Moretta, A.
AU - Moretta, L.
AU - Pende, D.
AU - Viale, O.
PY - 1992
Y1 - 1992
N2 - Human natural killer (NK) cells with the CD3- CD16+ phenotype recognize allospecificities on normal T-cell blasts. The NK-defined specificity 1 (NK- 1) is recessively inherited and has been mapped to the major histocompatibility complex between the complement gene cluster and HLA-A. A gene for NK-1, however, has not been identified. Here we demonstrate that NK- 1 and the recently defined NK specificity 2 (NK-2) are reciprocally associated with homozygosity for a diallelic polymorphism at amino acid positions 77 and 80 in the putative peptide-binding site of HLA-C (P < 10- 5). NK-cell recognition of allogeneic cells may, therefore, be controlled by HLA-C itself or by a closely linked gene(s), which dominantly prevents (resistance alleles) or recessively permits (susceptibility alleles) recognition of still-unknown target determinants.
AB - Human natural killer (NK) cells with the CD3- CD16+ phenotype recognize allospecificities on normal T-cell blasts. The NK-defined specificity 1 (NK- 1) is recessively inherited and has been mapped to the major histocompatibility complex between the complement gene cluster and HLA-A. A gene for NK-1, however, has not been identified. Here we demonstrate that NK- 1 and the recently defined NK specificity 2 (NK-2) are reciprocally associated with homozygosity for a diallelic polymorphism at amino acid positions 77 and 80 in the putative peptide-binding site of HLA-C (P < 10- 5). NK-cell recognition of allogeneic cells may, therefore, be controlled by HLA-C itself or by a closely linked gene(s), which dominantly prevents (resistance alleles) or recessively permits (susceptibility alleles) recognition of still-unknown target determinants.
UR - http://www.scopus.com/inward/record.url?scp=0026686544&partnerID=8YFLogxK
U2 - 10.1073/pnas.89.17.7983
DO - 10.1073/pnas.89.17.7983
M3 - Article
C2 - 1518825
AN - SCOPUS:0026686544
SN - 0027-8424
VL - 89
SP - 7983
EP - 7985
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 17
ER -