All in the family: Using inherited cancer syndromes to understand de-regulated cell signaling in brain tumors

S. Sean Houshmandi, David H. Gutmann

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

The cell signaling pathways that are tightly regulated during development are often co-opted by cancer cells to allow them to escape from the constraints that normally limit cell growth and cell movement. In this regard, deregulated signaling in cancer cells confers a number of key tumor-associated properties, including increased cell proliferation, decreased cell death, and increased cell motility. The identification of some of these critical signaling pathways in the nervous system has come from studies of inherited cancer syndromes in which affected individuals develop brain tumors. The study of brain tumors arising in patients with neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), and tuberous sclerosis complex (TSC) has already uncovered several key intracellular signaling pathways important for modulating brain tumor growth. An in-depth analysis of these intracellular signaling pathways will not only lead to an improved understanding of the process of brain tumorigenesis, but may also provide important molecular targets for future therapeutic drug design.

Original languageEnglish
Pages (from-to)811-819
Number of pages9
JournalJournal of cellular biochemistry
Volume102
Issue number4
DOIs
StatePublished - Nov 1 2007

Keywords

  • Brain tumor signaling
  • Merlin
  • NF1
  • NF2
  • Neurofibromatosis 1
  • Neurofibromatosis 2
  • Neurofibromin
  • Schwannomin
  • TSC1/hamartin
  • TSC2/tuberin
  • Tuberous sclerosis complex

Fingerprint

Dive into the research topics of 'All in the family: Using inherited cancer syndromes to understand de-regulated cell signaling in brain tumors'. Together they form a unique fingerprint.

Cite this