Aldolase forms a bridge between cell surface adhesins and the actin cytoskeleton in apicomplexan parasites

Travis J. Jewett, L. David Sibley

Research output: Contribution to journalArticle

255 Scopus citations

Abstract

Host cell invasion by apicomplexan parasites requires coordinated interactions between cell surface adhesins and the parasite cytoskeleton. We have identified a complex of parasite proteins, including the actin binding protein aldolase, which specifically interacts with the C-terminal domains of several parasite adhesins belonging to the thrombospondin-related anonymous protein (TRAP) family. Binding of aldolase to the adhesin was disrupted by mutation of a critical tryptophan in the C domain, a residue that was previously shown to be essential for parasite motility. Our findings reveal a potential role for aldolase in connecting TRAP family adhesins with the cytoskeleton, and provide a model linking adhesion with motility in apicomplexan parasites.

Original languageEnglish
Pages (from-to)885-894
Number of pages10
JournalMolecular cell
Volume11
Issue number4
DOIs
StatePublished - Apr 1 2003

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