@article{f0536f74198a4df2ad403cd7e692cbab,
title = "Aldolase forms a bridge between cell surface adhesins and the actin cytoskeleton in apicomplexan parasites",
abstract = "Host cell invasion by apicomplexan parasites requires coordinated interactions between cell surface adhesins and the parasite cytoskeleton. We have identified a complex of parasite proteins, including the actin binding protein aldolase, which specifically interacts with the C-terminal domains of several parasite adhesins belonging to the thrombospondin-related anonymous protein (TRAP) family. Binding of aldolase to the adhesin was disrupted by mutation of a critical tryptophan in the C domain, a residue that was previously shown to be essential for parasite motility. Our findings reveal a potential role for aldolase in connecting TRAP family adhesins with the cytoskeleton, and provide a model linking adhesion with motility in apicomplexan parasites.",
author = "Jewett, {Travis J.} and Sibley, {L. David}",
note = "Funding Information: We thank Gary Ward, Con Beckers, Vern Carruthers, Takashi Asai, and Dominique Soldati for providing reagents and/or helpful discussions, Mark Crankshaw and David McCourt for assistance with protein identification, Alisa Weaver, Fabien Brossier, and Naomi Morrissette for critical review of the manuscript, and Stephan Kapp{\'e} and Bill Bergman for sharing unpublished data prior to publication. This work was supported in part by a grant from the National Institutes of Health (AI 34036). L.D.S. is a recipient of a Scholar Award in Molecular Parasitology from the Burroughs Wellcome Fund. T.J.J. was partially supported by an NIH Institutional Training Grant to Washington University (AI017172). ",
year = "2003",
month = apr,
day = "1",
doi = "10.1016/S1097-2765(03)00113-8",
language = "English",
volume = "11",
pages = "885--894",
journal = "Molecular cell",
issn = "1097-2765",
number = "4",
}