Alcohol dependence and reproductive timing in African and European Ancestry women: Findings in a midwestern twin cohort

Mary Waldron, Kathleen K. Bucholz, Pamela A.F. Madden, Alexis E. Duncan, Carolyn E. Sartor, Andrew C. Heath

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objective: We examined associations between reproductive onset and history of alcohol dependence (AD) in 475 African ancestry (AA) and 2, 865 European or other ancestry (EA) female twins. Method: Participants were drawn from a U.S. midwestern birth cohort study of like-sex female twin pairs born between 1975 and 1985, ages 21-32 as of last completed assessment. Cox proportional hazards regression models were estimated predicting age at first childbirth from history of AD, separately by race/ethnicity, without and with adjustment for sociodemographic characteristics, body mass index, history of other substance involvement, psychopathology, and family and childhood risks. Results: Among EA twins, AD predicted early childbearing through age 17 and delayed childbearing from age 25 onward; in adjusted models, AD was associated with overall delayed childbearing. Among AA twins, reproductive timing and AD were not significantly related in either unadjusted or adjusted models. Conclusions: Findings for twins of European ancestry are consistent with well-documented links between early alcohol mis/use and teenage parenting as well as delays in childbearing associated with drinking-related reproductive and relationship difficulties. Extension of analyses to other racial/ethnic groups of sufficient sample size remains important.

Original languageEnglish
Pages (from-to)235-240
Number of pages6
JournalJournal of Studies on Alcohol and Drugs
Volume75
Issue number2
DOIs
StatePublished - 2014

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