Alcohol Binge-Induced Cardiovascular Dysfunction Involves Endocannabinoid–CB1-R Signaling

Janos Paloczi, Csaba Matyas, Resat Cinar, Zoltan V. Varga, György Hasko, Thomas H. Schindler, George Kunos, Pal Pacher

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Excessive binge alcohol drinking may adversely affect cardiovascular function. In this study we characterize the detailed hemodynamic effects of an acute alcohol binge in mice using multiple approaches and investigate the role of the endocannabinoid–cannabinoid 1 receptor (CB1-R) signaling in these effects. Acute alcohol binge was associated with elevated levels of cardiac endocannabinoid anandamide and profound cardiovascular dysfunction lasting for several hours and redistribution of circulation. These changes were attenuated by CB1-R antagonist or in CB1-R knockout mice. Our results suggest that a single alcohol binge has profound effects on the cardiovascular system, which involve endocannabinoid–CB1-R signaling.

Original languageEnglish
Pages (from-to)625-637
Number of pages13
JournalJACC: Basic to Translational Science
Volume4
Issue number5
DOIs
StatePublished - Sep 2019

Keywords

  • binge alcohol drinking
  • cannabinoids
  • contractility
  • endocannabinoids

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