Abstract
The effects of acute alcohol administration on myo-inositol and myo-inositol 1-phosphate levels in the male rat cerebral cortex were examined. At a dose of 3 g/kg, alcohol reduced myoinositol 1-phosphate levels in the cortex by 60% within 30 min after its injection. A significant depression in myo-inositol 1-phosphate was found 5 min after the injection of alcohol, and maximal levels of depression occurred at 30 min. Levels of myo-inositol 1-phosphate remained significantly depressed for 6 hr and then gradually recovered, reaching normal values 24-hr after the initial injection. There was an excellent inverse correlation (rxy = 0.96) between myo-inositol 1-phosphate levels and blood alcohol levels at all time intervals examined. Dose-response analyses indicated that the half-maximal (ED50) decrease in myo-inositol 1-phoshate levels occurred at a dose of 1.6 g/kg of alcohol. In contrast to these effects, myo-inositol levels were not significantly altered by any dose of alcohol any time interval examined. Because of the rapidity of changes in myo-inositol 1-phosphate after acute alcohol administration and the excellent negative correlation between blood alcohol levels and changes in myo-inositol 1-phosphate, alcohol-induced alterations in myo-inositol 1-phosphate appear to be the direct effect of alcohol per se and may participate in the acute pharmacological effects of the drug.
| Original language | English |
|---|---|
| Pages (from-to) | 24-27 |
| Number of pages | 4 |
| Journal | Journal of Pharmacology and Experimental Therapeutics |
| Volume | 213 |
| Issue number | 1 |
| State | Published - Jan 1 1980 |