Akt in human colorectal cancer

Kumar S. Bishnupuri, Satheesh K. Sainathan

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Colorectal cancer (CRC) is a commonly diagnosed cancer in both men and women and the leading cause of cancer death in the US and Europe. A better understanding of gene regulation and signal transduction pathways involved in colorectal carcinogenesis is required to substantially improve the treatments of human CRC. Akt/PKB is a serine/threonine protein kinase that plays a key role in mediating signals for cell growth, cell survival (anti-apoptotic), cell-cycle progression, differentiation, transcription, translation, and glucose metabolism. Akt1 also known as Akt is primarily involved in cellular survival and apoptotic pathways. Since it blocks apoptosis, and promotes cell survival, Akt has been implicated as a major factor in many types of cancer. This chapter is focused on defining the regulators of Akt and role of Akt in mediating signaling pathways in human CRC.

Original languageEnglish
Title of host publicationSignaling, Gene Regulation and Cancer
PublisherNova Science Publishers, Inc.
Pages121-136
Number of pages16
ISBN (Print)9781619420885
StatePublished - Dec 1 2012

Keywords

  • Carcinoma
  • Cyclin
  • Cyclin-dependent kinase
  • EGFR
  • GPCR
  • GSK-3
  • Insulin

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