Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation

Natalia Jaeger; Ryan T. McDonough; Anne L. Rosen; Ariel Hernandez-Leyva; Naomi G. Wilson; Michael A. Lint; Emilie V. Russler-Germain; Jiani N. Chai; Leonard B. Bacharier; Chyi Song Hsieh; Andrew L. Kau

doi:10.1016/j.celrep.2020.108331

Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation

Natalia Jaeger, Ryan T. McDonough, Anne L. Rosen, Ariel Hernandez-Leyva, Naomi G. Wilson, Michael A. Lint, Emilie V. Russler-Germain, Jiani N. Chai, Leonard B. Bacharier, Chyi Song Hsieh, Andrew L. Kau

Research output: Contribution to journal › Article › peer-review

Abstract

Asthma is known to be modified by airway microbes. Jaeger et al. use a murine-adapted bacterium to show that airway colonization evokes a Th17 response associated with increased SLPI, an antimicrobial peptide, and protection from lung inflammation. In people, SLPI was correlated with airway microbiota composition.

Original language	English
Article number	108331
Journal	Cell Reports
Volume	33
Issue number	5
DOIs	https://doi.org/10.1016/j.celrep.2020.108331
State	Published - Nov 3 2020

Keywords

Bordetella pseudohinzii
Haemophilus
T helper 17 (Th17)
airway microbiome
airway microbiota
allergic airway inflammation
antimicrobial peptide
asthma
interleukin-17 (IL-17)
secretory leukocyte protease inhibitor (SLPI)

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10.1016/j.celrep.2020.108331

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Jaeger, N., McDonough, R. T., Rosen, A. L., Hernandez-Leyva, A., Wilson, N. G., Lint, M. A., Russler-Germain, E. V., Chai, J. N., Bacharier, L. B., Hsieh, C. S., & Kau, A. L. (2020). Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation. Cell Reports, 33(5), [108331]. https://doi.org/10.1016/j.celrep.2020.108331

Jaeger, Natalia ; McDonough, Ryan T. ; Rosen, Anne L. ; Hernandez-Leyva, Ariel ; Wilson, Naomi G. ; Lint, Michael A. ; Russler-Germain, Emilie V. ; Chai, Jiani N. ; Bacharier, Leonard B. ; Hsieh, Chyi Song ; Kau, Andrew L. / Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation. In: Cell Reports. 2020 ; Vol. 33, No. 5.

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title = "Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation",

abstract = "Asthma is known to be modified by airway microbes. Jaeger et al. use a murine-adapted bacterium to show that airway colonization evokes a Th17 response associated with increased SLPI, an antimicrobial peptide, and protection from lung inflammation. In people, SLPI was correlated with airway microbiota composition.",

keywords = "Bordetella pseudohinzii, Haemophilus, T helper 17 (Th17), airway microbiome, airway microbiota, allergic airway inflammation, antimicrobial peptide, asthma, interleukin-17 (IL-17), secretory leukocyte protease inhibitor (SLPI)",

author = "Natalia Jaeger and McDonough, {Ryan T.} and Rosen, {Anne L.} and Ariel Hernandez-Leyva and Wilson, {Naomi G.} and Lint, {Michael A.} and Russler-Germain, {Emilie V.} and Chai, {Jiani N.} and Bacharier, {Leonard B.} and Hsieh, {Chyi Song} and Kau, {Andrew L.}",

year = "2020",

month = nov,

day = "3",

doi = "10.1016/j.celrep.2020.108331",

language = "English",

volume = "33",

journal = "Cell Reports",

issn = "2211-1247",

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Jaeger, N, McDonough, RT, Rosen, AL, Hernandez-Leyva, A, Wilson, NG, Lint, MA, Russler-Germain, EV, Chai, JN, Bacharier, LB, Hsieh, CS & Kau, AL 2020, 'Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation', Cell Reports, vol. 33, no. 5, 108331. https://doi.org/10.1016/j.celrep.2020.108331

Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation. / Jaeger, Natalia; McDonough, Ryan T.; Rosen, Anne L.; Hernandez-Leyva, Ariel; Wilson, Naomi G.; Lint, Michael A.; Russler-Germain, Emilie V.; Chai, Jiani N.; Bacharier, Leonard B.; Hsieh, Chyi Song ; Kau, Andrew L.

In: Cell Reports, Vol. 33, No. 5, 108331, 03.11.2020.

Research output: Contribution to journal › Article › peer-review

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AU - McDonough, Ryan T.

AU - Rosen, Anne L.

AU - Hernandez-Leyva, Ariel

AU - Wilson, Naomi G.

AU - Lint, Michael A.

AU - Russler-Germain, Emilie V.

AU - Chai, Jiani N.

AU - Bacharier, Leonard B.

AU - Hsieh, Chyi Song

AU - Kau, Andrew L.

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KW - Haemophilus

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KW - airway microbiome

KW - airway microbiota

KW - allergic airway inflammation

KW - antimicrobial peptide

KW - asthma

KW - interleukin-17 (IL-17)

KW - secretory leukocyte protease inhibitor (SLPI)

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