@article{ba2fd47e219e4484b186539992b06b32,
title = "Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation",
abstract = "Asthma is known to be modified by airway microbes. Jaeger et al. use a murine-adapted bacterium to show that airway colonization evokes a Th17 response associated with increased SLPI, an antimicrobial peptide, and protection from lung inflammation. In people, SLPI was correlated with airway microbiota composition.",
keywords = "Bordetella pseudohinzii, Haemophilus, T helper 17 (Th17), airway microbiome, airway microbiota, allergic airway inflammation, antimicrobial peptide, asthma, interleukin-17 (IL-17), secretory leukocyte protease inhibitor (SLPI)",
author = "Natalia Jaeger and McDonough, {Ryan T.} and Rosen, {Anne L.} and Ariel Hernandez-Leyva and Wilson, {Naomi G.} and Lint, {Michael A.} and Russler-Germain, {Emilie V.} and Chai, {Jiani N.} and Bacharier, {Leonard B.} and Hsieh, {Chyi Song} and Kau, {Andrew L.}",
note = "Funding Information: We thank Tarisa Mantia, Caitlin O{\textquoteright}Shaughnessy, and Shannon Rook for their assistance with patient recruitment and members of the Kau lab for helpful discussions. We would also like to thank MARS study participants and their families. The research was supported by the AAAAI Foundation Faculty Development Award (to A.L.K.), the American Asthma Foundation (to C.-S.H. and A.L.K.), and NIH grants T32 GM007200 (to A.L.R.), R01 AI136515 (to C.-S.H.) and K08 AI113184 (to A.L.K.). Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = nov,
day = "3",
doi = "10.1016/j.celrep.2020.108331",
language = "English",
volume = "33",
journal = "Cell Reports",
issn = "2211-1247",
number = "5",
}