Abstract
Asthma is known to be modified by airway microbes. Jaeger et al. use a murine-adapted bacterium to show that airway colonization evokes a Th17 response associated with increased SLPI, an antimicrobial peptide, and protection from lung inflammation. In people, SLPI was correlated with airway microbiota composition.
Original language | English |
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Article number | 108331 |
Journal | Cell Reports |
Volume | 33 |
Issue number | 5 |
DOIs | |
State | Published - Nov 3 2020 |
Keywords
- Bordetella pseudohinzii
- Haemophilus
- T helper 17 (Th17)
- airway microbiome
- airway microbiota
- allergic airway inflammation
- antimicrobial peptide
- asthma
- interleukin-17 (IL-17)
- secretory leukocyte protease inhibitor (SLPI)