Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation

Natalia Jaeger, Ryan T. McDonough, Anne L. Rosen, Ariel Hernandez-Leyva, Naomi G. Wilson, Michael A. Lint, Emilie V. Russler-Germain, Jiani N. Chai, Leonard B. Bacharier, Chyi Song Hsieh, Andrew L. Kau

Research output: Contribution to journalArticlepeer-review

Abstract

Asthma is known to be modified by airway microbes. Jaeger et al. use a murine-adapted bacterium to show that airway colonization evokes a Th17 response associated with increased SLPI, an antimicrobial peptide, and protection from lung inflammation. In people, SLPI was correlated with airway microbiota composition.

Original languageEnglish
Article number108331
JournalCell Reports
Volume33
Issue number5
DOIs
StatePublished - Nov 3 2020

Keywords

  • Bordetella pseudohinzii
  • Haemophilus
  • T helper 17 (Th17)
  • airway microbiome
  • airway microbiota
  • allergic airway inflammation
  • antimicrobial peptide
  • asthma
  • interleukin-17 (IL-17)
  • secretory leukocyte protease inhibitor (SLPI)

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