TY - JOUR
T1 - Airway epithelial cells suppress T cell proliferation by an IFNγ/STAT1/TGFβ-dependent mechanism
AU - Deppong, Christine M.
AU - Xu, Jian
AU - Brody, Steven L.
AU - Green, Jonathan M.
PY - 2012/1
Y1 - 2012/1
N2 - Organ-specific regulation of immune responses relies on the exchange of information between nonimmune and immune cells. In a primary culture model of the lung airway, we demonstrate that T cell proliferation is potently inhibited by airway epithelial cells (ECs). This is mediated by activation of the IFNγ/STAT1 pathway in the EC and transforming growth factor-β (TGFβ)-dependent suppression of T cell proliferation. In this way, the EC can restrict the expansion of T cells. Given the constant exposure of the airway to inhaled antigen, this may be important in setting a threshold for the initiation of T cell-dependent immune responses and preventing unwanted, chronic inflammation.
AB - Organ-specific regulation of immune responses relies on the exchange of information between nonimmune and immune cells. In a primary culture model of the lung airway, we demonstrate that T cell proliferation is potently inhibited by airway epithelial cells (ECs). This is mediated by activation of the IFNγ/STAT1 pathway in the EC and transforming growth factor-β (TGFβ)-dependent suppression of T cell proliferation. In this way, the EC can restrict the expansion of T cells. Given the constant exposure of the airway to inhaled antigen, this may be important in setting a threshold for the initiation of T cell-dependent immune responses and preventing unwanted, chronic inflammation.
KW - Lung inflammation
KW - Lymphocyte proliferation
KW - Lymphocytes
UR - http://www.scopus.com/inward/record.url?scp=83755178999&partnerID=8YFLogxK
U2 - 10.1152/ajplung.00188.2011
DO - 10.1152/ajplung.00188.2011
M3 - Article
C2 - 22003092
AN - SCOPUS:83755178999
VL - 302
SP - L167-L173
JO - American Journal of Physiology - Lung Cellular and Molecular Physiology
JF - American Journal of Physiology - Lung Cellular and Molecular Physiology
SN - 0002-9513
IS - 1
ER -