Air Pollution Exposure during Pregnancy and Fetal Markers of Metabolic function

Eric Lavigne, Jillian Ashley-Martin, Linda Dodds, Tye E. Arbuckle, Perry Hystad, Markey Johnson, Dan L. Crouse, Adrienne S. Ettinger, Gabriel D. Shapiro, Mandy Fisher, Anne Sophie Morisset, Shayne Taback, Maryse F. Bouchard, Liu Sun, Patricia Monnier, Renee Dallaire, William D. Fraser

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Previous evidence suggests that exposure to outdoor air pollution during pregnancy could alter fetal metabolic function, which could increase the risk of obesity in childhood. However, to our knowledge, no epidemiologic study has investigated the association between prenatal exposure to air pollution and indicators of fetal metabolic function. We investigated the association between maternal exposure to nitrogen dioxide and fine particulate matter (aerodynamic diameter ≤2.5 μm) and umbilical cord blood leptin and adiponectin levels with mixed-effects linear regression models among 1,257 mother-infant pairs from the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, conducted in Canada (2008-2011). We observed that an interquartile-range increase in average exposure to fine particulate matter (3.2 μg/m3) during pregnancy was associated with an 11% (95% confidence interval: 4, 17) increase in adiponectin levels. We also observed 13% (95% confidence interval: 6, 20) higher adiponectin levels per interquartile-range increase in average exposure to nitrogen dioxide (13.6 parts per billion) during pregnancy. Significant associations were seen between air pollution markers and cord blood leptin levels in models that adjusted for birth weight z score but not in models that did not adjust for birth weight z score. The roles of prenatal exposure to air pollution and fetal metabolic function in the potential development of childhood obesity should be further explored.

Original languageEnglish
Pages (from-to)842-851
Number of pages10
JournalAmerican journal of epidemiology
Volume183
Issue number9
DOIs
StatePublished - May 1 2016
Externally publishedYes

Keywords

  • Air pollution
  • birth cohort
  • leptin
  • maternal exposure
  • pregnancy
  • umbilical cord blood

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    Lavigne, E., Ashley-Martin, J., Dodds, L., Arbuckle, T. E., Hystad, P., Johnson, M., Crouse, D. L., Ettinger, A. S., Shapiro, G. D., Fisher, M., Morisset, A. S., Taback, S., Bouchard, M. F., Sun, L., Monnier, P., Dallaire, R., & Fraser, W. D. (2016). Air Pollution Exposure during Pregnancy and Fetal Markers of Metabolic function. American journal of epidemiology, 183(9), 842-851. https://doi.org/10.1093/aje/kwv256